Searchable abstracts of presentations at key conferences on calcified tissues

ba0005cabs.op2.2 | Oral Poster Talks | ECTS2016

Mesenchymal stromal cells promote osteosarcoma stemness and migratory potential via IL-6 secretion

Cortini Margherita , Avnet Sofia , Bonuccelli Gloria , Baldini Nicola

Osteosarcoma (OS) is an aggressive malignancy characterized by a high relapse rate despite multiagent chemotherapy. As for other cancers, OS microenvironment contributes to tumor initiation, growth, and metastasis. We consider bone marrow mesenchymal stromal cells (MSC) as a major nontumor component of OS microenvironment, and have previously found that the interaction between MSC and tumor cells is bidirectional, i.e. tumor cells can modulate their peripheral environment that...