Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p226 | Energy metabolism and bone, fat and bone | ECTS2016

Osteocalcin interacts with brain-derived neurotrophic factor, nerve growth factor but not oxytocin in the regulation of bone, energy, brain and reproductive functions

Camerino Claudia , Caloiero Roberta , Conte Elena , Tricarico Domenico

Osteocalcin, the neurotrophins BDNF/NGF and Oxytocin(Oxt) have pleiotropic effects on energy metabolism, bone mass, reproduction and brain functions suggesting a coordinated regulation. The carboxylated osteocalcin(Ost) acts on bone, while the uncarboxylated Ost shows hormone-like actions. NGF regulates female fertility elevating LH, Ost−/− mice show high LH in spite of decreased testosterone. BDNF/NGF-Oxt-Ost interactions was investigated by RT-PCR meas...