Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Poster Presentations

Energy metabolism and bone, fat and bone

ba0005p222 | Energy metabolism and bone, fat and bone | ECTS2016

Changes in circulating osteocalcin concentration in overweight and obese adult women having normal glucose and hemoglobin A1c levels

Zeni Susana , Zago Liliana , Gonzalez Infantino Carlos A , Carlos Lugones , Brito Graciela , Dana Watson , Beatriz Oliveri

Osteocalcin (OC) plays crucial roles in glucose homeostasis. OC level in the circulation appears to be associated with glucose and fat metabolism – Although still it remains controversial if it are the levels of total OC and/or undercarboxilated OC (ucOC) which present such association. The present study evaluated the levels of ucOC, total OC, leptin and insulin, in 226 overweight or obese (degree I and II) adult non-diabetic women, having levels of glucose (80–110 m...

ba0005p223 | Energy metabolism and bone, fat and bone | ECTS2016

Cyclic AMP/protein kinase A signalling downregulates Dlx5 expression via inducing C/Ebpβ in 3T3-L1 preadipocytes

Baek Jeong-Hwa , Lee Hye-Lim , Qadir Abdul , Kim Hyun Jeong , Chung Jin , Woo Kyung Mi , Ryoo Hyun-Mo

Distal-less homeobox 5 (Dlx5) is a transcription factor that enhances osteogenic differentiation of mesenchymal stem cells via upregulating the expression of Runx2 and other osteoblast phenotypic genes. We have previously demonstrated that Dlx5 also downregulates adipogenic differentiation of mesenchymal stem cells and that insulin decreases expression levels of Dlx5 via increasing expression levels of miR-124, a microRNA targeting 3′UTR of Dlx5. However, the mechanism o...

ba0005p224 | Energy metabolism and bone, fat and bone | ECTS2016

Osteocalcin downregulates pancreatic lipase expression in GPRC6A dependent manner

Baek Kyunghwa , Ko Seong-Hee , Hwang Hyo Rin , Kwon Yewon , Baek Jeong-Hwa

We previously elucidated that β-adrenergic blockade attenuates high fat diet induced obesity development and such an effect is associated with suppressed pancreatic lipase (PNLIP) expressions. In the present study, we tested whether β-adrenergic blockade downregulates bioactive osteocalcin secretion in osteoblasts, thereby reduces PNLIP secretion in pancreatic acinar cells.Forty of male 6wk old C57BL/6 mice were assigned into control diet (CON)...

ba0005p225 | Energy metabolism and bone, fat and bone | ECTS2016

Association between bone turnover markers and leptin in girls with adolescent idiopathic scoliosis (AIS)

Matusik Edyta , Durmala Jacek , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy , Matusik Pawel

The link between scoliotic deformity and bone metabolism in adolescent idiopathic scoliosis (AIS) has not been well researched. Moreover, the data concerning the cross-talk between leptin level and bone markers in this group of patients are lacking. The objective of this study was to correlate the extent of scoliotic-curve severity with the bone turnover and leptin level in girls with AIS. The study encompassed 77 AIS girls, aged 14.7±2.17 years. Scoliotic curve severity ...

ba0005p226 | Energy metabolism and bone, fat and bone | ECTS2016

Osteocalcin interacts with brain-derived neurotrophic factor, nerve growth factor but not oxytocin in the regulation of bone, energy, brain and reproductive functions

Camerino Claudia , Caloiero Roberta , Conte Elena , Tricarico Domenico

Osteocalcin, the neurotrophins BDNF/NGF and Oxytocin(Oxt) have pleiotropic effects on energy metabolism, bone mass, reproduction and brain functions suggesting a coordinated regulation. The carboxylated osteocalcin(Ost) acts on bone, while the uncarboxylated Ost shows hormone-like actions. NGF regulates female fertility elevating LH, Ost−/− mice show high LH in spite of decreased testosterone. BDNF/NGF-Oxt-Ost interactions was investigated by RT-PCR meas...

ba0005p227 | Energy metabolism and bone, fat and bone | ECTS2016

The role of interleukin-6 and tumor necrosis factor alpha gene in fat and bone communication

Wang Chunyu , Tian Li , Zhang Kun , Chen Yaxi , Chen Xiang , Xie Ying , Zhao Qian , Yu Xijie

Objective: To comparing the role of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in fat and bone communication.Methods: Male wild type (WT) mice, IL-6 knockout (IL-6−/−) mice, and tumor necrosis factor alpha (TNF-α) were fed with either standard diet (SD) or high fat diet (HFD) for 12 weeks. Bone mass and bone microstructure were evaluated by micro-CT. Gene expression related to lipid and bone metabolisms ...

ba0005p228 | Energy metabolism and bone, fat and bone | ECTS2016

Effects of roux-en-Y gastric bypass surgery on bone quality: a pilot study

Hogestol I.K. , Paschalis E.P. , Gamsjaeger S. , Hassler N. , Shabestari M.G. , Gulseth H.L. , Mala T. , Klaushofer K. , Eriksen E.F.

Roux-en-Y gastric bypass surgery (RYGBP) is one of the leading surgical treatments for morbid obesity and leads to significant long-term weight loss, diabetes remission, decreased cardiovascular events, and reduced mortality. RYGBP is, however, also implicated in increased fracture risk, mainly due to higher bone turnover rates and malabsorption. In the present study we used Raman microspectroscopic analysis to determine bone quality (an important determinant of bone strength)...

ba0005p229 | Energy metabolism and bone, fat and bone | ECTS2016

Impaired adipose tissue inflammation results in increased bone mineral density in mice

Grahnemo Louise , Gustafsson Karin , Asterholm Wernstedt Ingrid , Lagerquist Marie

Obesity, diabetes, and high fracture risk is linked, but the mechanism is unclear. However, impaired acute adipose tissue inflammation may be a common denominator for these conditions. Impaired adipose tissue inflammation leads to low adipogenesis, insufficient adipose expansion, and signs of diabetes.The aim of this study was to investigate if the low adipogenesis induced by impaired adipose tissue inflammation is coupled to increased osteoblastogenesis...

ba0005p230 | Energy metabolism and bone, fat and bone | ECTS2016

The interrelationship of 25-hydroxyvitamin D and osteocalcin on glycolipid metabolism: a cross-sectional study in type 2 diabetics

Su Junlei , Xu Mingxin , Hao Jie , Zhang Zhiyin , Zhong Ni , Cui Ran , Xu Bei , Li Feng , Feng Tienan , Zhang Ge , Sheng Hui , Qu Shen

Context: As bone metabolic markers, recent studies indicated vitamin D and osteocalcin (OC) were also involved in energy metabolism. While the exact relationship between vitamin D and OC in regulating energy metabolism is unclear. One of the possibilities is that: low vitamin D could lead to secondary hyperparathyroidism and following high bone turnover, which would enhance the quantity of bioactive OC.Objective: Our aim was to study whether OC mediated ...

ba0005p231 | Energy metabolism and bone, fat and bone | ECTS2016

Osteocalcin transgenic mice reveal aspects of the bone/glucose axis, as well as powerful suppression of ectopic osteocalcin protein production

Horsnell Harry , Wee Natalie , Kulkarni Rishikesh , Herzog Herbert , Baldock Paul

Rationale: Mice deficient in osteocalcin show an impaired glucose tolerance, however, the exact mechanism involved have yet to be fully elucidated. We aimed to overexpress osteocalcin to determine its effect on glucose homeostasis and explore the signalling pathway involved. We wished to expand upon previous preliminary data suggesting that this pathway involve neuropeptide Y (NPY) signalling.Objective: To analyse the in vivo and in vitro</e...

ba0005p232 | Energy metabolism and bone, fat and bone | ECTS2016

Significant correlation between vasculopathy and bone mineral density in T2DM: new light shed on diabetic osteoporosis

Zhong Ni , Xu Mingxin , Su Junlei , Zhang Zhiyin , Cui Ran , Ma Yuelong , Sheng Chunjun , Zhang Ge , Sheng Hui , Qu Shen

Purpose: Osteoporosis (OP) aggravates with vasculature degeneration and improvement of vasculature could prevent OP. We, thus, hypothesize that vascular structure and function play an important role in the development of OP. Type 2 diabetes mellitus (T2DM) patients are vulnerable to vasculopathy, so T2DM were involved in this project to study the correlation between vasculopathy and bone mineral density (BMD).Methods: A total of 427 (180 in OP group; 247...