ECTS2016 Poster Presentations Energy metabolism and bone, fat and bone (11 abstracts)
Significant correlation between vasculopathy and bone mineral density in T2DM: new light shed on diabetic osteoporosis
Ni Zhong 1 , Mingxin Xu 1 , Junlei Su 1 , Zhiyin Zhang 1 , Ran Cui 1 , Yuelong Ma 1 , Chunjun Sheng 1 , Ge Zhang 2 , Hui Sheng 1 & Shen Qu 1
1Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, China; 2The Chinese University of Hong Kong, Hong Kong, China.
Purpose: Osteoporosis (OP) aggravates with vasculature degeneration and improvement of vasculature could prevent OP. We, thus, hypothesize that vascular structure and function play an important role in the development of OP. Type 2 diabetes mellitus (T2DM) patients are vulnerable to vasculopathy, so T2DM were involved in this project to study the correlation between vasculopathy and bone mineral density (BMD).
Methods: A total of 427 (180 in OP group; 247 in non-OP group) postmenopausal women with T2DM were consecutively involved. Data on baseline characteristics were collected. Vasculopathy severity and BMD were respectively evaluated by carotid ultrasonography (GE L05, LOGIQ 5) and dual energy X-ray absorptiometry (Hologic QDR4500W). Patients were assigned into two categories (OP=1 or non-OP=2) according to BMD. A semiquantitative scale score (score 0–4, the score higher, the plaques more sever) using University of Washington criteria was used to assess the severity of carotid plaques. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equation. Logistic regression analysis was used to study the association between BMD and vasculopathy. All subjects agreed to participate in the study with written informed consent.
Results: Compared with non-OP group, OP group was illustrated with high scores of carotid plaque (1.67±1.55 vs 1.27±0.42, P=0.008) and decreased eGFR (79.32±23.40 vs 84.03±25.19 ml/min/1.73 m2, P=0.002). Moreover, notably higher levels of osteocalcin and C-terminal telopeptide fragments of type I collagen (CTX) were observed in OP group compared with non-OP group. Multivariate logistic regression analysis in all patients revealed that BMD was negatively correlated with age (r=−0.104, P<0.001), and carotid plaque score (r=−0.132, P=0.023), while positively correlated with BMI (r=0.175, P<0.001), HDL (r=1.254, P=0.009) and eGFR (r=0.19, P=0.038).
Conclusion: The results demonstrate a positive correlation between BMD and vasculopathy in postmenopausal women with T2DM, providing evidence for further investigation of T2DM-relative OP.
Volume 5
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