Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp139 | Cancer and bone: basic, translational and clinical | ECTS2013

New PI3Kα-specific inhibitor, BYL719: therapeutic interest in osteosarcoma

Gobin Berengere , Baud'huin Marc , Charrier Celine , Hervouet Soizic , Lezot Frederic , Blanchard Frederic , Heymann Dominique

It has been established that disturbances of intracellular signaling pathways strongly contribute to the oncologic process. Indeed, phosphatidylinositol-3-kinase (PI3K) became a key target in cancer therapy, due to its high frequency of mutation and/or gain of function of its catalytic subunits in cancer cells. In this context, we investigated the in vitro and in vivo effects of a new PI3Kα inhibitor, BYL719 (Novartis Pharma), on bone cells and its thera...

ba0003pp156 | Cell biology: osteoclasts and bone resorption | ECTS2014

Interleukin-34 and macrophage-colony stimulating factor interact to form a heteromeric and functional cytokine

Segaliny Aude , Brion Regis , Brulin Benedicte , Teletchea Stephane , Jardin Julien , Maillasson Mike , Charrier Celine , Heymann Dominique

Interleukin-34 (IL-34) is a newly discovered cytokine which regulates, like macrophage-colony stimulating factor (M-CSF), the differentiation/activation of the myeloid lineage. IL-34 and M-CSF are homodimers known to bind to the M-CSF receptor (M-CSFR) in a competitive manner. In this system, IL-34 can substitute for the M-CSF to induce osteoclastic differentiation. The aim of the present work was to study the functional relationships of these cytokines on cells expressing the...

ba0003pp95 | Cancer and bone: basic, translational and clinical | ECTS2014

Interleukin 34 promotes angiogenesis and increases blood cells adherence to endothelial cells

Segaliny Aude , Mohamadi Amel , Dizier Blandine , Lokajczyk Anna , Brion Regis , Charrier Celine , Boisson-Vidal Catherine , Heymann Dominique

Tumour growth and metastatic dissemination are significantly reduced in mice bearing an inactivation of the macrophage-colony stimulating factor (M-CSF) gene, due to angiogenesis impairment. In fact, M-CSF directly induces angiogenesis by increasing vascular endothelial growth factor (VEGF) production. Interleukin 34 (IL34), the M-CSF’s ‘twin’ cytokine, was characterized as a new cytokine promoting the growth, survival and differentiation of the myeloid lineage....