Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p488 | Preclinical and ex vivo imaging | ECTS2016

Mandibular bone: an unusual trabecular bone?

Coutel Xavier , Olejnik Cecile , Marchandise Pierre , Chauveau Christophe , Penel Guillaume

Introduction: Mandibular alveolar bone appears to be particularly sensitive to local factors compared to other skeletal sites. In growing rats, occlusal hypofunction leads to a dramatic decrease of the alveolar bone microarchitecture. Intra-radicular bone surrounding teeth is a specific functional area with a high bone turnover. We hypothesized that the mechanical loading of the alveolar process during mastication may play a role in the preservation of the alveolar bone microa...

ba0001pp471 | Other diseases of bone and mineral metabolism | ECTS2013

Long-term energy deficiency in mice induces bone alterations reversed by long-term recovery

Zgheib Sara , Lucas Stephanie , Mequinion Mathieu , Broux Odile , Leterme Damien , Hardouin Pierre , Viltart Odile , Chauveau Christophe

Anorexia nervosa (AN) a condition of profound undernutrition, is characterized by alterations in neuroendocrine and metabolic functions. Among the serious pathological consequences of this eating disorder, osteoporosis is often observed and persists after recovery, leading to a high fracture risk.To study particularly bone alterations and recovery, a long term mouse model has been developed. In this model named separation-based anorexia (SBA) – a ch...

ba0005p81 | Bone Marrow | ECTS2016

Increased bone marrow adiposity in energy deficit context: tip of the iceberg?

Ghali Olfa , Leterme Damien , Coutel Xavier , Resonet Anne , Marchandise Pierre , Miellot Flore , Penel Guillaume , Hardouin Pierre , Chauveau Christophe

Context: An increase in bone marrow adiposity (BMA) is usually described in anorexia nervosa (AN) patients and in calorie restriction models. This induced BMA could be involved in the development of the osteoporosis often described in AN. However, BMA increase is not always observed and could be depending on the severity of the deficit.We previously developed the separation-based anorexia mouse model (SBA)1 (Ethical approval CEEA #022012). SBA...

ba0001pp178 | Cell biology: osteoblasts and bone formation | ECTS2013

Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

Deschaseaux Frederic , Gaillard Julien , Langonne Alain , Chauveau Christophe , Naji Abderrahim , Bouacida Amina , Rosset Philippe , Heymann Dominique , de Pinieux Gonzague , Rouas-Freiss Nathalie , Sensebe Luc

Bone-marrow mesenchymal stem cells (MSCs) are the origin of bone-forming cells with immunomodulation potential. Among the generated immunosuppressive molecules there is HLA-G5. HLA-G proteins play a crucial role in promoting the acceptance of allografts. However, the mechanisms regulating the expression of HLA-G5 in human MSCs are unknown. We induced differentiation of human MSCs (harvested from iliac crests of healthy volunteers after their informed consent following approved...