Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp46 | Bone biomechanics and quality | ECTS2013

Low magnitude vibration signals attenuate the rapid bone mass induced by lipopolysaccharide

Kim In Sook , Cho Tae Hyung , Lee Beomseok , Hwang Soon Jung

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

ba0001pp47 | Bone biomechanics and quality | ECTS2013

Osseous alterations in condylar head after directional change of functional loading in rabbit mandibular condyle

Hwang Soon Jung , Yang Hoon Joo , Cho Tae Hyung , Oh Ji Hye , Kim In Sook

Purpose: The purpose of this study was to investigate the bony change of mandibular condyle when the originally less-loaded or unloaded surface was subjected to functional loading by the newly designed animal experiment, and to evaluate whether this experiment is adequate for the animal model of condylar resorption due to mechanical loading.Methods: Twelve adult male New Zealand white rabbits were used. Unilateral oblique vertical body osteotomy (UOVBO) ...

ba0001pp487 | Other diseases of bone and mineral metabolism | ECTS2013

Preliminary study for the effect of PDGF or mesenchymal stem cells on tissue repair of cutaneous radiation injury

Hwang Soon Jung , Cho Tae Hyung , Lee Beomseok , Oh Ji Hye , Kim In Sook

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...

ba0003pp129 | Cell biology: osteoblasts and bone formation | ECTS2014

Modulation of sclerostin expression by estrogen via BMP-2 signaling in human mesenchymal stromal cells and osteoblasts

Kim Ri Youn , Yang Hoon Joo , Song Yun Mi , Cho Tae Hyung , Hwang Soon Jung , Kim In Sook

Little is known about the molecular mechanisms underlying the interaction between Sclerostin (SOST) and estrogen, showing an inverse relation in clinical data. Therefore, we investigated mechanisms by which estrogen modulates Sost expression at human osteoblastic cell level in association with BMP-2 signaling, which is a potential route of SOST induction. BMP-2 significantly induced SOST expression, which is suppressed by 17β-estradiol (E2) in human mesenchymal s...