Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp288 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Decrease in expression of MMP3 in osteoblast protects against bone loss

Zarka-Prost-Dumont Mylene , Jehan Frederic , Ostertag Agnes , de Vernejoul Marie-Christine , Geoffroy Valerie

Osteoblastic MMPs are important actors of bone remodeling. We showed previously that osteoblast specific overexpression of TIMP1, an inhibitor of MMPs, prevents the bone loss induced by ovariectomy mainly through inhibition of bone resorption. We hypothesized that inhibition of the MMP3 could be implicated in the protective effect of TIMP1 and that MMP3 polymorphisms located in the proximal promoter of MMP3 gene could be associated to post-menopausal bone loss in women.<p ...

ba0001pp316 | Osteoporosis: evaluation and imaging | ECTS2013

Cortical and trabecular bone parameters from HR-Pqct images at the Tibia: a local comparison with synchrotron radiation micro-computed tomography

Ostertag Agnes , Peyrin Francoise , Fernandez Sylvie , Laredo Jean-Denis , De Vernejoul Marie-Christine , Chappard Christine

In clinical research protocols, HR-pQCT images (XtremCT Scanco, voxel size: 82 (μm3) are carried out to evaluate trabecular and cortical bone changes induced by osteoporosis and treatments. Micro-computed tomography (μ-CT) has become a standard tool for examination of trabecular and cortical bone in 3D.The purpose of this study is to evaluate the accuracy of cortical and trabecular measurements derived from HR-pQCT images with morpho...