Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

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European Calcified Tissue Society Congress 2013, 18 - 22 May 2013; Lisbon, Portugal

Poster Presentations

Osteoporosis: evaluation and imaging

ba0001pp310 | Osteoporosis: evaluation and imaging | ECTS2013

Osteoporosis and osteopenia of the spine in rheumatic patients, treated with glucocorticosteroids

Haroyan Armine , Ghukasyan Liana

Introduction: The purpose of this study was to determine osteoporosis (OP) and osteopenia in patients with various rheumatic diseases depending on the duration of use glucocorticosteroids (GCS) and daily dose of GCS.Methods: The study included 125 patients (90 women and 25 men) with various rheumatic diseases receiving GCS therapy. BMD was measured by DXA (Hologic). Patients were divided into two groups. Group I included postmenopausal women and men over...

ba0001pp311 | Osteoporosis: evaluation and imaging | ECTS2013

Appropriate osteoporosis treatment by family physicians in response to FRAX vs caroc reporting: a randomized controlled trial

Beattie Karen , Ioannidis George , MacDermid Joy , Grewal Ruby , Papaioannou Alexandra , Hodsman Anthony , Adachi Jonathan D

Introduction: Current Canadian clinical practice guidelines recommend the FRAX or Canadian Association of Radiologists and Osteoporosis Canada (CAROC) fracture risk assessment tools to report 10-year fracture risk in an individual. CAROC considers sex, age, BMD and previous fracture as risk factors. It is unknown whether one reporting system is more effective in helping general practitioners (GPs) identify individuals who should be recommended for pharmacological treatment. We...

ba0001pp312 | Osteoporosis: evaluation and imaging | ECTS2013

Correlation of bioelectrical impendance analysis and dual energy X-ray absorptiometry for bone mineral content and bone mineral density in young healthy humans

Cvetko Erna Davidovic , Nesic Nebojsa , Milas-Ahic Jasminka , Drenjancevic Ines

Introduction: Bioelectrical impendance analysis (BIA) and dual enargy X-ray absorptiometry (DXA) are two most common methods used for body composition analysis. The aim of this study was to investigate: i) if there is a correlation between body mineral content (BMC) determined by BIA and by DXA for bone mineral content (BMC) and ii) correlation of BMC (BIA) vs bone mineral density (BMD) of L1–L4 spine, dual femur total mean and neck mean.Methods: Tw...

ba0001pp313 | Osteoporosis: evaluation and imaging | ECTS2013

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis

Bobinac Dragica , Celic Tanja , Marinovic Marin , Maric Ivana

The aim was to explore whether osteoporosis in humans influences the morphological status of the cartilage and subchondral bone, and relationship between macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone. Femoral heads were obtained from 68 patients with osteoporosis (OP) and hip OA (OP, n=56; OA, n=12) during hip surgery. Evaluation of the cartilage degeneration was done by Mankin g...

ba0001pp314 | Osteoporosis: evaluation and imaging | ECTS2013

Communication of fracture risk and treatment benefit in terms of ‘bone health age’ using FRAX or Qfracture

Abrahamsen Bo , Rubin Katrine Hass , Hansen Carrinna , Brixen Kim

Introduction: Communication of absolute and relative risks is challenging despite the development of tools to quickly derive absolute fracture risk estimates from risk factors with or without BMD. We speculated that back-transformation of risks to a risk age could make for a clearer message and at the same time increase agreement between risk algorithms.Results: The algorithms differed less in estimated bone health age than in percent risk. A 60 years ol...

ba0001pp315 | Osteoporosis: evaluation and imaging | ECTS2013

The stability of intact parathyroid hormone in human blood during different sampling conditions and long-term storage in serum tubes

Andersen Camilla Sand , Hoeck Hans Christian , Gazerani Parisa , Vestergaard Peter

Objective: To investigate i) the analytic stability of PTH in venous blood specimens in serum tubes processed at different time intervals after collection compared to immediately processed blood samples collected in K2EDTA tubes, and ii) whether storage of samples in serum tubes for 5 years at −20 °C had an effect on stability of PTH.Methods: Venous blood samples were collected from ten healthy Caucasian females. One K2EDTA tube and three seru...

ba0001pp316 | Osteoporosis: evaluation and imaging | ECTS2013

Cortical and trabecular bone parameters from HR-Pqct images at the Tibia: a local comparison with synchrotron radiation micro-computed tomography

Ostertag Agnes , Peyrin Francoise , Fernandez Sylvie , Laredo Jean-Denis , De Vernejoul Marie-Christine , Chappard Christine

In clinical research protocols, HR-pQCT images (XtremCT Scanco, voxel size: 82 (μm3) are carried out to evaluate trabecular and cortical bone changes induced by osteoporosis and treatments. Micro-computed tomography (μ-CT) has become a standard tool for examination of trabecular and cortical bone in 3D.The purpose of this study is to evaluate the accuracy of cortical and trabecular measurements derived from HR-pQCT images with morpho...

ba0001pp317 | Osteoporosis: evaluation and imaging | ECTS2013

A 3D QCT technique of the thoracic and lumbar spine: integral volume and intervertebral disc space increase and bmd decreases from T6 to L4

Museyko Oleg , Heinemann Axel , Krause Mattias , Barkmann Reinhard , Amling Michael , Gluer Claus , Puschel Klaus , Engelke Klaus

Introduction: QCT of the spine is typically restricted to the BMD analysis of the lumbar vertebrae. However, fractures frequently occur in the thoracolumbar region. Also the load distribution in the spine may depend on the intervertebral disc space (IDS), a good approximation of the intervertebral disc, which itself cannot be reliably assessed by X-ray based methods.Materials and methods: A QCT 3D acquisition and automated analysis technique (with option...

ba0001pp318 | Osteoporosis: evaluation and imaging | ECTS2013

Binding kinetics of fluorescent bisphosphonates as a tool for monitoring bone dynamics in vivo

Tower Robert , Campbell Graeme , Muller Marc , Will Olga , Grundmann Frederieka , Schem Christian , Gluer Claus , Tiwari Sanjay

Bone resorption and deposition occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance between bone synthesis and resorption, including osteoporosis and skeletal metastases. The uncoupling of remodeling activities contributes to disseminated tumor cells homing to the bone and to tumor growth in bone. Therefore, a reliable marker of bone remodeling would be useful to provide a st...

ba0001pp319 | Osteoporosis: evaluation and imaging | ECTS2013

Prevalence of FRAX clinical risk factors: dietary calcium intake habits and osteoporosis screening in Greek women

Bakides Sofoclis , Sakellariadis George , Alevizou Stavroula , Koussi Kleoniki , Rapti Anna , Tsiverdis Panayiotis , Kavvadia Konstantina , Drivas Kyriakos , Ververeli Charilila-Loukia

Introduction: Osteoporosis-related fractures can cause substantial disability and increase health care costs, and mortality. There are many difficulties to access Greek women residing in remote villages and perform the FRAX tool for osteoporosis evaluation, especially, after the global economy crisis.Purpose: To estimate the prevalence of FRAX clinical risk factors, calcium intake habits and perform osteoporosis screening in 275 postmenopausal Greek wome...

ba0001pp320 | Osteoporosis: evaluation and imaging | ECTS2013

Quantitative ultrasound of os calcis BMD vs conventional DXA and peripheral QCT in interval assessment of BMD changes in adolescent females

To William W K , Wong Margaret W N

Objective: To compare whether interval BMD changes in adolescent females that can be detected using conventional dual energy X-ray absorptiometry (DXA) can also be detected using quantitative peripheral quantitative computerized tomography scans (pQCT) and quantitative ultrasound (QUS)of the os calcis.Methods: Two groups of adolescent females were recruited for assessment of BMD changes over an interval of 22–24 months. These included full time coll...

ba0001pp321 | Osteoporosis: evaluation and imaging | ECTS2013

Use of os calcis quantitative ultrasound for bone mineral density screening in adolescents with menstrual dysfunction

To William W K , Wong Margaret W N

Background: Prolonged hypothalamic amenorrhoea with anovulation has been associated with hypo-oestrogenism in adolescents and has been shown to be associated with lower bone mineral density (BMD) values.Objective: To determine whether differences in BMD between oligo/amenorrhoeic adolescents at risk of low BMD and normal eumenorrhoeic controls can be detectable by quantitative ultrasound (QUS) of the os calcis.Methods: Adolescents ...

ba0001pp322 | Osteoporosis: evaluation and imaging | ECTS2013

Comparative assessment of bone mineral density of the femoral neck between dual-energy X-ray absorptiometry and a new ultrasonic method

Conversano Francesco , Casciaro Ernesto , Greco Antonio , Pisani Paola , Franchini Roberto , Grimaldi Antonella , Quarta Eugenio , Muratore Maurizio , Casciaro Sergio

Introduction: Recently reported high incidences of hip fractures emphasize the need of more effective methods for osteoporosis diagnosis, currently performed essentially by dual-energy X-ray absorptiometry (DXA) examinations of the proximal femur. However, high costs and radiation-related issues do not allow DXA employment for population mass screenings. Aim of this study is to carry out a preliminary clinical validation of a new ultrasound (US)-based method to perform femoral...

ba0001pp323 | Osteoporosis: evaluation and imaging | ECTS2013

A new ultrasonic method for diagnosis of osteoporosis on hip and spine

Casciaro Sergio , Conversano Francesco , Casciaro Ernesto , Franchini Roberto , Maria Daniela Renna , Greco Antonio , Quarta Eugenio , Quarta Laura , Muratore Maurizio

Introduction: Currently, the only available method to reliably predict osteoporotic fractures is represented by bone mineral density (BMD) measurements on proximal femur or spine, which require the use of X-rays. Aim of this study is to illustrate working principles and feasibility of a new ultrasound (US) method for bone densitometry and osteoporosis diagnosis applicable on both proximal femur and spine.Methods: A new fully automatic algorithm was devel...

ba0001pp324 | Osteoporosis: evaluation and imaging | ECTS2013

Strong diagnostic agreement between a novel ultrasound-based method for lumbar densitometry and dual-energy X-ray absorptiometry

Muratore Maurizio , Conversano Francesco , Casciaro Ernesto , Soloperto Giulia , Franchini Roberto , Greco Antonio , Quarta Eugenio , Casciaro Sergio

Introduction: Currently, osteoporosis is mainly diagnosed through dual-enargy X-ray absorptiometry (DXA). However, DXA cannot be used for early diagnoses through population mass screenings because of issues related to ionizing radiation employment. Aim of this study is to perform a preliminary clinical validation of a new ultrasound (US)-based method for vertebral densitometry.Methods: A total of 270 women were included in this study according to the fol...

ba0001pp325 | Osteoporosis: evaluation and imaging | ECTS2013

Relationship between quantitative ultrasound parameters at calcaneous and health-related quality of life domains in postmenopausal Italian women: the FEDRO study

Gonnelli Stefano , Caffarelli Carla , Guglielmi Giuseppe , Rossi Stefania , Adami Silvano , Nuti Ranuccio

Reduced bone mineral density (BMD) has been reported to adversely affect health related quality of life (HRQoL) also in postmenopausal women without vertebral fracture. To date no data exist in literature about any possible influences of quantitative ultrasonography (QUS) on HRQoL. This study aimed to assess whether QUS parameters at calcaneous may be associated with HRQoL.In 1812 ambulatory postmenopausal women aged 60 years or over, referred by their f...

ba0001pp326 | Osteoporosis: evaluation and imaging | ECTS2013

FRAXture:- does FRAX reflect the risk of fracture in real practice?

Aguiar Renata , Pinho Romeu , Merinhos Tiago , Ambrosio Catarina , Barcelos Anabela

Introduction: The FRAX algorithm, by evaluating the 10-year risk of hip and major osteoporotic fractures, weights greatly on the clinicians’ decision to treat a patient with an antiosteoporotic drug. The FRAX tool has recently been validated for the Portuguese population.With this work, the authors intended to assess FRAX accuracy when retrospectively performed in patients with hip fracture.Methods: A retrospective cohort stud...

ba0001pp327 | Osteoporosis: evaluation and imaging | ECTS2013

BMA assessment standard curves for wrist and ankle of both sexes: data from EpiReumaPt

Canhao Helena , Gouveia Nelia , Rego Tania , Rodrigues Ana Maria , Branco Jaime

Introduction: To determine bone microarchitecture analysis (BMA) standard curves for wrist and ankle in men and women.Design: EpiReumaPt is an ongoing national, population-based, cross-sectional, epidemiologic study developed by the Portuguese Society of Rheumatology to estimate the prevalence of rheumatic diseases in Portugal. Trained interviewers have been randomly applying a standardized questionnaire to 10 000 subjects at their houses. Selected cases...

ba0001pp328 | Osteoporosis: evaluation and imaging | ECTS2013

Bone mineral density distribution in early osteoporotic bone

Abdulghani Saba , Santos Luis , Vidal Bruno , Cascao Rita , Fonseca Joao

Osteoporosis (OP) is characterised by low bone mass and microarchitectural deterioration of the bone tissue, leading to enhanced bone fragility and increased fracture risk. OP causes an imbalance in the cellular remodelling process thus inducing changes in the bone’s mineral and organic phases that are responsible for its strength and stiffness. The purpose of this study is to investigate the early effects of OP progression on the arrangement of bone tissue mineral phase ...

ba0001pp329 | Osteoporosis: evaluation and imaging | ECTS2013

Discordance of Z-score in healthy premenopausal women with BMD below the expected range of age and contributing factors: the Korea national health and nutrition examination survey 2008–2009

Sung-Kil Lim , Park Kyeong Hye , Kim Kyoung Min , Lim Jung Soo , Rhee Yumie

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...

ba0001pp330 | Osteoporosis: evaluation and imaging | ECTS2013

Factors that affects on bone density in premenopausal women

Lee Dong Ock , Choi Hoon , Kim Jung Gu

Objectives: To find the predicting factors for bone density in premenopausal women.Methods: Two hundred and forty-five premenopausal women without factors that can cause secondary osteoporosis were analyzed. Age, height, weight, change of height from peak height, history (Hx) of fracture, family Hx of hip or other fracture, Hx of estrogen use, calcium or vitamin D supplementation, smoking and previous Hx of amenorrhea more than 3 months were questioned. ...

ba0001pp331 | Osteoporosis: evaluation and imaging | ECTS2013

May we screen with FRAX clinical factors?

Barbu Carmen Gabriela , Poiana Catalina , Ionita Dariana , Gascan Magda , Stefan Cristina , Stefanopol Aurelia , Fica Simona

Aim: The aim of the study was to evaluate the usefulness of the fracture risk evaluated through the FRAX® model based only on the clinical risk factors as a screening tool for identify the target population for treatment in osteoporosis.Materials and methods: Two hundred and seventy-six postmenopausal women treatment naive referred to two different endocrinology departments for osteoporosis between 2009 and 2011 were evaluated. The FRAX® model ...

ba0001pp332 | Osteoporosis: evaluation and imaging | ECTS2013

Osteoporosis and bone fractures in elder women with rheumatoid arthritis

Kasumova Kamalya , Satybaldyev Azamat , Smirnov Alexander

Introduction: Objective of the study is to assess the frequency of osteoporosis and osteoporotic fractures in rheumatoid arthritis (RA) patients with the onset in the age of 55 and elder.Methods: Seventy women with RA (mean age of 62.6 years, mean RA duration of 4.6 years) were examined with dual X-ray absorptiometry (DXA) in three locations (vertebral body L1–L4, femoral neck, and distal radius) and X-ray of vertebral with assessment by Felsenberg....

ba0001pp333 | Osteoporosis: evaluation and imaging | ECTS2013

Calcification of the coronary arteries among the males with coronary heart disease and osteoporosis

Malyuta Elena , Raskina Tatiana , Barbarash Olga , Kokov Alexandr

Subject: To examine the relationship between calcification of the coronary arteries, coronary atherosclerosis and indicators of bone mineral density (BMD) among males with coronary heart disease (CHD).Materials and methods: Seventy-four males with documented CHD were examined. BMD was assessed by dual energy absorptiometry with T-criterion definition of the proximal femur and lumbar spine, coronarography, multispiral computed tomography with quantificati...

ba0001pp334 | Osteoporosis: evaluation and imaging | ECTS2013

Bone fragility in patients with alcoholic liver cirrhosis: can hip structure analysis better predict risk of hip fracture

Djonic Danijela , Culafic Djordje , Culafic-Vojinovic Violeta , Ignjatovic Svetlana , Soldatovic Ivan , Vasic Jelena , Djuric Marija

Hepatic osteodystrophy is an important complication of chronic liver disease associated with fractures resulting in pain, deformity and immobility. The aim of the study was to examine association of severity of alcoholic liver cirrhosis with areal bone mineral density (BMD) and to estimate bone geometric strength of the proximal femur in those patinets. The study included 27 male patients with alcoholic liver cirrhosis and control group of 36 healthy patients. Laboratory testi...

ba0001pp335 | Osteoporosis: evaluation and imaging | ECTS2013

Usefulness of bone turnover markers in the evaluation of fracture risk in type 2 diabetes

Rozas-Moreno Pedro , Reyes-Garcia Rebeca , Garcia-Martin Antonia , Lopez-Gallardo Gema , Garcia-Fontana Beatriz , Morales-Santana Sonia , Munoz-Torres Manuel

Introduction: The utility of the determination of bone turnover markers in the evaluation of fracture risk at the patient level is not well-established. In type 2 diabetes (T2DM) there is an increased risk of fractures despite of higher bone mineral density. A recent study shows that a femoral neck T-score of −2.1 in males and −1.9 in females with T2DM present the same fracture risk than subjects without diabetes with a T-score −2.5 (Schwart...

ba0001pp336 | Osteoporosis: evaluation and imaging | ECTS2013

TBS improves the detection of subjects at risk of fracture irrespectively to the BMD status: a Spanish population-based study

Gregorio Silvana Di , Winzenrieth Renaud , Rio Luis Del

Iisn’t uncommon to encounter patients with both a fragility fracture and only a slightly low BMD value or even normal one. Currently the DXA technology can assess information on trabecular microstructural texture supplementing the standard BMD measurement, using a new method: the trabecular bone score (TBS). In order to check TBS, BMD and their combination to discriminate patients with vertebral fracture, we scanned 946 subjects. The cohort was stratified using the WHO di...

ba0001pp337 | Osteoporosis: evaluation and imaging | ECTS2013

Dietary calcium and vitamin D intake and serum 25-hydroxyvitamin D and parathyroid hormone levels in healthy elderly Spanish men: the relationship with calcaneal and phalangeal quantitative ultrasound and phalangeal dual energy X-ray absorptiometry

Leal Alejo , Luz Canal-Macias Maria , Fernando Calderon-Garcia Julian , Roncero-Martin Raul , Rodriguez-Dominguez Trinidad , Moran Jose M

Purpose: To evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) at the phalanges and the calcaneus in independent elderly men from southwestern Spain.Methods: Serum PTH and 25(OH)D were measured in 199 healthy elderly men (mean age: 73.31...

ba0001pp338 | Osteoporosis: evaluation and imaging | ECTS2013

Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men

Lavado-Garcia Jesus Maria , Rey-Sanchez Purificacion , Costa-Fernandez Carmen , Martinez Mariana , Leal Alejo , Rodriguez-Velasco Francisco Jose , Pedrera-Zamorano Juan Diego

Context: Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels.Aims: To examine the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men.Methods and material: We examined 162 me...

ba0001pp339 | Osteoporosis: evaluation and imaging | ECTS2013

What is the performance in vertebral fracture discrimination by bone mineral density, micro-architecture estimation, and FRAX in stand-alone, combined or adjusted approaches: the OsteoLaus Study

Lamy Olivier , Krieg Marc-Antoine , Stoll Delphine , Aubry-Rozier Berengere , Metzger Marie , Hans Didier

The aim of the study is to compare the performance of FRAX vs TBS adjusted FRAX using Leslie B et al.1 method to better identify women at high fracture risk. The OsteoLaus cohort (1500 women 50–80 years living in Lausanne, CH) started in 2010. CRF for OP, FRAX, spine and hip BMD, VFA by DXA and TBS were recorded. Sensitivity and specificity in regard to vertebral fracture grade 2 and 3 has been calculated. Net reclassification improvement (NRI) had als...

ba0001pp340 | Osteoporosis: evaluation and imaging | ECTS2013

Trabecular bone score and bone mineral density of lumbar spine in healthy women: pros and cons

Povoroznyuk Vladyslav , Lamy O , Dzerovych Nataliia , Hans Didier

Areal bone mineral density (aBMD) of the PA spine and proximal femur remained the gold standard for WHO classification of osteoporosis, fracture prediction and patient monitoring. Unfortunately, with age it is not infrequent to observe the presence of degenerative disease such as spinal osteoarthritis which would have a positive artifactual impact on aBMD which could lead to an erroneous interpretation. In a previous study it has been demonstrated that apparently such artifact...