Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

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European Calcified Tissue Society Congress 2013, 18 - 22 May 2013; Lisbon, Portugal

Poster Presentations

Muscle, physical activity and bone

ba0001pp284 | Muscle, physical activity and bone | ECTS2013

Raising CK: what it means according to different clinical landscape?

Juan Jose Scali , Visentini Susana , Berruezo Ramiro , Sevilla Daniel , Pacheco Gonzalo , Garcia Rodrigo

Introduction: The creatine kinase (CK) is a dimeric enzyme, involved in energetical metabolism. It is present in many tissues, but higher concentration in skeletal and cardiac muscle.Therefore, conditions that involve muscle tissue may increase this serum enzyme. Such enzyme elevation is usually observed in inflammatory myopathies and others autoimmune diseases.Sometimes some elevation in CK is not fully understood out off these co...

ba0001pp285 | Muscle, physical activity and bone | ECTS2013

Prolonged botulinum toxin type A-induced muscle paralysis results in loss of bone mineral density and bone strength in young female rats

Ellegaard Maria , Syberg Susanne , Jorgensen Niklas Rye , Schwarz Peter

Transient paralysis by a single injection of botulinum toxin type A (Botox) in rodents has been shown to cause local bone loss of the affected leg. The animals regain function of the leg within 3–4 weeks and bone loss slowly recovers. The duration of the paralysis is dose-dependent. However, higher doses of Botox cause weight loss and decreased activity level.Aim of study was to investigate whether repeated injections of low-dose Botox could induce ...

ba0001pp286 | Muscle, physical activity and bone | ECTS2013

Muscle function and quality of life in primary hyperparathyroidism

Rolighed Lars , Amstrup Anne Kristine , Jakobsen Niels Frederik Breum , Sikjaer Tanja , Mosekilde Leif , Christiansen Peer , Rejnmark Lars

Introduction: In spite of the frequent encounter of ‘asymptomatic’ primary hyperparathyroidism (PHPT), the patients often describe various relevant improvements postoperatively suggesting a subclinical biological effect of elevated PTH or hypercalcaemia.Materials and methods: To evaluate muscle function, postural stability, and quality of life (QoL) in untreated PHPT, we assessed maximal isometric muscle strength in upper and lower extremities,...

ba0001pp287 | Muscle, physical activity and bone | ECTS2013

Muscle strength and peripheral fractures in osteoporotic patients

Schober Hans-Christof , Hamann Franka , Torner Johanna

Introduction: Osteoporosis and fractures are multifactorial events. Muscle weakness and changes in bone density are of special importance. The aim of this study was to determine wether clinically applicable physical tests could be used to identify the relation between physical performance and fractures.Methods: Data of 179 community dwelling female patients (mean age 74±5.4 years) suffering osteoporosis were retrospectively investigated. Peripheral ...

ba0001pp288 | Muscle, physical activity and bone | ECTS2013

Microgravity modulates nitric oxide homeostasis in vascular system

Thagaraj Pradeep , Chatterjee Suvro

Microgravity causes adverse health problems to astronauts during space flight, especially to bone, heart, and muscles. The vascular system plays a central role in various organs and the skeletal tissues. This new environment makes vascular adaptation difficult. Nitric oxide plays an essential role in the vascular system by modulating basal vascular tone. An alteration of NO metabolism or bioavailability has been thought to be one of the main factors for vascular disorders. Res...

ba0001pp289 | Muscle, physical activity and bone | ECTS2013

The outcomes and costs of falls in elderly women

Tamulaityte-Morozoviene Inga , Alekna Vidmantas , Stukas Rimantas , Tamulaitiene Marija

Objective: To examine the outcomes and costs of direct medical care for falls in elderly women in Lithuania.Methods: Women aged 65 years and older, who visited National Osteoporosis Center for diagnostic or treatment procedures. Thereafter a telephone survey was performed using the questionnaire with 28 questions about the number, circumstances, and consequences of falls. The cost of health care due to fall was estimated after calculating the sum of cost...

ba0001pp290 | Muscle, physical activity and bone | ECTS2013

Response of mechanically strained tenocytes to different cell culture substrates

Musson David , JungJoo Kim , Callon Karen , Naot Dorit , Shim Vickie , Anderson Iain , Cornish Jillian , Chhana Ashika

The musculoskeletal system experiences severe mechanical strain, with repetitive or extreme strains causing significant trauma; the result being an increase in mechanobiological studies evaluating mechanical strain on musculoskeletal cells. Currently, most stretching studies utilise fibronectin-coated cultures, as these enhance cell attachment. However, recent studies suggest that fibronectin increases cell turnover and DNA damage and affects cell differentiation. Furthermore,...

ba0001pp291 | Muscle, physical activity and bone | ECTS2013

Physical activity, bone metabolism and inflammatory markers, and bone mineral density in elderly men: a preliminary investigation

Marques Elisa , Mota Jorge , Viana Joao , Figueiredo Pedro , Guimaraes Joao , Carvalho Joana

Introduction: Most studies to date have focus on the effect of exercise interventions on bone remodeling. Furthermore, inflammation has been associated with those critical for bone physiology and remodeling. However, investigations analyzing the relationship between objective physical activity and bone metabolism and inflammatory markers and the potential interactions with BMD and body composition in older men are limited, which is the aim of the present study.<p class="ab...

ba0001pp292 | Muscle, physical activity and bone | ECTS2013

Sex-specific association of physical activity with bone mass distribution at the femoral neck and trochanter in young adults

Zymbal Vera , Rebocho Lurdes , Cardadeiro Graca , Baptista Fatima

Women suffer more fragility fractures in old age and have a higher incidence of fractures at the femoral neck region compared to men who have higher incidence of trochanteric femoral fractures. The purpose of this cross-sectional study was to analyze associations between physical activity (PA) and bone mass distribution at the femoral neck (FN) and trochanter (TR) in young adults. A left hip DXA scan was used to measure bone mineral density (BMD) at the integral, superolateral...

ba0001pp293 | Muscle, physical activity and bone | ECTS2013

Sarcopenia in patients with spondyloarthritis: is there any relation with radiological damage?

Aguiar Renata , Merinhos Tiago , Sequeira Joana , Ambrosio Catarina , Barcelos Anabela

Introduction: The loss of muscle mass (MM) is a serious problem which has been demonstrated in patients with rheumatoid arthritis. There are few studies about the loss of MM in patients with spondyloarthritis (Spa). In a recent case–control study in our department, the risk of sarcopenia in Spa patients was twice than in a healthy control group.Objective: To assess muscle mass index (MMI) in patients with axial Spa and to search a relation between s...

ba0001pp294 | Muscle, physical activity and bone | ECTS2013

Influence of mechanical loading and skeleton geometry in bone mass at the proximal femur in 10–12 years old children: a longitudinal study

Cardadeiro Graca , Baptista Fatima , Rosati Nicolleta , Zymbal Vera , Rebocho Lurdes , Bruno Paula M , Janz Kathleen F , Sardinha Luis B

Using a longitudinal observational study with two evaluations and a 1 year follow-up interval, we investigated the influence of everyday physical activity (PA) and skeletal geometry in bone mineral density (BMD) and bone mass distribution at the proximal femur (PF) in 96 girls and 81 boys (10–12 years). Whole body and left hip DXA scans were used to derive geometric measures of the pelvis (inter acetabular distance – IAD) and PF (abductor lever arm – ALA). BMD w...

ba0001pp295 | Muscle, physical activity and bone | ECTS2013

Proximal femur geometry as moderator factor for the effect of mechanical loading during gait: a bone remodeling analysis

Machado Miguel M , Fernandes Paulo R , Baptista Fatima

The regions of the proximal femur that are at greater risk of structural failure during a fall are those with less adaptive protection promoted by mechanical loading of the activities of daily living. Considering the associations between bone geometry of the proximal femur with bone fracture risk, we intended to examine how geometrical characteristics of the proximal femur (FNL, femoral neck length; FNW, femoral neck width; NSA, neck shaft angle) moderate the effect of mechani...

ba0001pp296 | Muscle, physical activity and bone | ECTS2013

Body composition relationship in Korean old people

Choi Woong H , Hong Sang M

Background: Recently, the prevalence of osteoporosis and sarcopenia in the elderly has dramatically increased. However the relationship between theses disease is not clear.Object: We aimed to determine the independent relations of muscle mass to osteoporosis (femur neck) in relation to body weight, fat mass, and other confounders.Design: We analyzed body composition and BMD data of 570 males and 734 females who are older than 65 ye...

ba0001pp297 | Muscle, physical activity and bone | ECTS2013

Prevalence of sarcopenia and its association with osteporosis in Korean postmenopausal women

Park Hyoung-Moo , Kim Tak

Introduction: Advancing age is associated with decline in bone and muscle mass and quality. Sarcopenia, one of Geriatric syndromes, is defined as the age-associated loss of skeletal muscle mass and function resulting in disability, poor QOL and death.Objective: To evaluate the prevalence of sarcopenia and its association with osteopenia/osteoporosis in Korean PMW.Materials and methods: Subjects: total 225 Korean PMW over 50 years w...

ba0001pp298 | Muscle, physical activity and bone | ECTS2013

The effects of vitamin D supplementation and fitness program for biochemistry, muscle mass and physical functions in elderly women

Yu Byung Yeon , Kim Kyung Soo , Kim In Kyung

The purpose of this study was to investigate the effects of fitness program with vitamin D supplementation for biochemistry related to vitamin D, muscle mass and physical functions in elderly women.The subjects were elderly women aged 65 or older, regularly visiting a senior welfare center and a senior citizen center in city. A total of 65 subjects were divided into experimental group (n=34) and control group (n=31). The intervention fo...

ba0001pp299 | Muscle, physical activity and bone | ECTS2013

Influence of gym high-intensity dynamic exercises and therapeutic exercises on functional status of patients with early rheumatoid arthritis

Orlova Evgeniya , Karateev Dmitry , Kochetkov Andrey , Mozhar Tatiana

Introduction: The patients with rheumatoid arthritis (RA) are less physically active than the general population. The aim of the study is to assess the effect of two exercise programs on the functional status of patients with early RA.Methods: Fifteen patients with early RA underwent ten high-intensity dynamic exercises using Enraf-Nonius gym for 45–60 min, including aerobic part (En-Cardio) and 18–20 muscle-strengthening exercises (En-Dynamic ...

ba0001pp300 | Muscle, physical activity and bone | ECTS2013

Vitamin D deficiency is associated with nonspecific skeletal pain in Saudi women

Hussein Khulood , Alkadi Hanan , Lanham-New Suzan , Ardawi Mohamad

Introduction and aims: Deficiency of vitamin D has been reported in subjects with many types of musculoskeletal pain. The aim of the present study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) and nonspecific skeletal pain in healthy Saudi women.Methods: Serum 25(OH)D were measured for 223 healthy women with nonspecific skeletal pain at different regions of the skeletal system including back pain. Serum 25(OH)D was measured...

ba0001pp301 | Muscle, physical activity and bone | ECTS2013

Effect of vitamin D status on muscle function and physical performance among saudi postmenopausal women: a cross-sectional study

Hussein Khulood

Introduction: Vitamin D deficiency is common among elderly subjects and is associated with reduced muscle strength. Although vitamin D deficiency is common among Saudi subjects, knowledge about its role in relation to muscle strength and physical performance is lacking. The objectives of the present study are to determine vitamin D status in a sample of randomly selected healthy postmenopausal Saudi women and to investigate the association between their serum 25(OH)D levels an...

ba0001pp302 | Muscle, physical activity and bone | ECTS2013

Morphology of muscle attachment sites and microarhitecture of underlying bone as the markers of physical activities of past populations

Djukic Ksenija , Milovanovic Petar , Hahn Michael , Busse Bjoern , Amling Michael , Djuric Marija

Habitual physical activities of past populations are frequently reconstructed based on musculoskeletal markers (MSM) in human skeletal remains, i.e. particular morphological features of muscles attachment sites. However, the relationship between muscular activity and bone microstructure at the site of muscle attachments is unexplored. Therefore, this study aimed at analyzing bone microstructural characteristics of the muscles attachments sites and correlating these features wi...

ba0001pp303 | Muscle, physical activity and bone | ECTS2013

The effect of different exercise modes on bone density in middle-aged and older men: a systematic review

Bolam Kate A , van Uffelen Jannique G Z , Taaffe Dennis R

Although trials have shown that exercise has positive effects on bone mineral density (BMD), not all exercise modalities are osteogenic and the majority of exercise trials have been conducted in older women. The aim of this study was to systematically review trials examining the effect of weight-bearing and resistance-based exercise modalities on the BMD of hip and lumbar spine of middle-aged and older men. Eight electronic databases were searched in August 2012. Only randomis...

ba0001pp304 | Muscle, physical activity and bone | ECTS2013

Everyday activity, important factors and quality of life in children and youths with osteogenesis imperfecta

Lowing Kristina , Hagberg Maude , Astrom Eva

Osteogenesis Imperfecta (OI) is in most cases a congenital disease of collagen. The mutations have been reported in COLIA1 and COLIA2 genes, localised to chromosomes 17 and 7 respectively. The incidence at birth is 6–20/100 000. Children and youths with OI often display a complex and heterogeneous picture with fragile skeleton, fractures, curvature in the long bones, short stature, pain and limitations in mobility and everyday activity. The impact of those factors for the...

ba0001pp305 | Muscle, physical activity and bone | ECTS2013

Associations of 25-hydroxyvitamin D concentrations with quality of life and self-rated health

Rafiq Rachida , Swart Karin , van Schoor Natasja , Deeg Dorly , Lips Paul , de Jongh Renate

Introduction: Vitamin D deficiency has been associated with impaired physical functioning and several chronic diseases and might thereby affect quality of life and self-rated health. The aim of this study was to assess relationships of serum 25-hydroxyvitamin D (25(OH)D) with quality of life and self-rated health, and to examine whether physical performance and number of chronic diseases mediate these relationships.Methods: Data were obtained from the LA...

ba0001pp306 | Muscle, physical activity and bone | ECTS2013

Increased activity associated with exercise does not rescue aged bone's impaired response to local mechanical loading

Meakin Lee , Udeh Chinedu , Sugiyama Toshihiro , Galea Gabriel , Lanyon Lance , Price Joanna

Bones’ fracture resistance is achieved in vivo by adaptation to habitual loading. Aged bone can adapt to exercise1 but in female rodents ageing impairs the adaptive response to artificial loading2,3. This inconsistency led us to investigate whether treadmill exercise, sufficiently mild to not itself stimulate new bone formation, could rescue aged bone’s diminished response to artificial loading.Young adult 17-week...

ba0001pp307 | Muscle, physical activity and bone | ECTS2013

Muscle power and force may influence cortical bone strength via distinct mechanisms: findings from a cross sectional study of high bone mass cases and controls

Hardcastle Sarah A , Gregson Celia L , Rittweger Jorn , Ward Kate A , Tobias Jon H

Background: Relationships between muscle function and bone have been examined using a range of techniques, with conflicting results. We aimed to determine these associations within an adult population comprising individuals with high bone mass and family controls.Methods: Recruitment was from four UK sites within the high bone mass (HBM) study; cases and unaffected family controls were pooled. Peak ground reaction force and peak power, during a multiple ...

ba0001pp308 | Muscle, physical activity and bone | ECTS2013

Sarcopenia in Ukrainian women of different age

Povoroznyuk Vladyslav , Dzerovych Nataliia

Aim: The aim of this study is evaluating of body composition and frequency of sarcopenia in women depending on age.Materials and methods: We have examined 8637 women aged 20–89 years (mean age – 56.7±0.14 years; mean height – 162.5±0.07 cm; mean weight – 73.5±0.16 kg). The patients were divided into two groups depending on age: 20–24 (n=143), 25–29 (n=209), 30–34 (n=271), 35&#15...

ba0001pp309 | Muscle, physical activity and bone | ECTS2013

Lean mass, not obesity, is related to total body bone mineral content in boys

Sanchez Tom , Wang Jingmei , Rajan Felix , Schwalenberg Terry , Dudzek Kathy

The literature has suggested that bone mineral content is modulated by muscle mass and activity. We investigated the relationship between DXA assessed total body bone mineral content, total body lean mass, appendicular lean mass and obesity (a possible marker of inactivity) in a population of 73 boys between the age of 7 and 19 using a Norland XR-46 system.Regression analysis shows that in these growing boys there is a strong positive relationship betwee...