Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc1.2 | Osteoporosis epidemiology and long term treatment complications | ECTS2013

Hip fractures and bone mineral density of the elderly: importance of serum 25-hydroxy vitamin D

Steingrimsdottir Laufey , Halldorsson Thorhallur , Siggeirsdottir Kristin , Cotch Mary Frances , Eiriksdottir Gudny , Sigurdsson Sigurdur , Harris Tamara , Gudnason Vilmundur , Sigurdsson Gunnar

Introduction: Vitamin D is known to be important for bone health. Still, the significance of serum 25-hydroxy vitamin D concentrations (s-25OHD) for hip fracture risk of the elderly is uncertain. Discordant findings may in part be explained by difficulties of RCTs or large cohort studies to reach both the frail and the healthy elderly. The objectives of this study were to determine the risk of hip fractures of the elderly related to s-25OHD, including both the frail and the he...

ba0005oc5.1 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

High serum miRNA 550a-5p levels are risk factors for incident fractures in older postmenopausal women with type 2 diabetes

Heilmeier Ursula , Hackl Matthias , Skalicky Susanna , Weilner Sylvia , Schroeder Fabian , Vierlinger Klemens , Lobach Iryna , Eiriksdottir Gudny , Aspelund Thor , Gudmundsson Elias , Grillari Johannes , Harris Tamara , Link Thomas , Gudnasson Vilmundur , Schwartz Ann

Standard DXA measurements, including FRAX scores, are limited in assessing fracture risk in type 2 diabetes (T2D). Novel, general applicable biomarkers are therefore needed. MicroRNAs (miRNAs) are secreted into the circulation from cells of various tissues proportional to local disease severity. Serum miRNA classifiers including miR-550a-5p were recently found to discriminate T2D women without and with prevalent fragility fractures with high specificity and sensitivity (AUC&#6...