Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Oral Communications

Risk factors for fracture, Pagets disease of bone and musle and bone

ba0005oc5.1 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

High serum miRNA 550a-5p levels are risk factors for incident fractures in older postmenopausal women with type 2 diabetes

Heilmeier Ursula , Hackl Matthias , Skalicky Susanna , Weilner Sylvia , Schroeder Fabian , Vierlinger Klemens , Lobach Iryna , Eiriksdottir Gudny , Aspelund Thor , Gudmundsson Elias , Grillari Johannes , Harris Tamara , Link Thomas , Gudnasson Vilmundur , Schwartz Ann

Standard DXA measurements, including FRAX scores, are limited in assessing fracture risk in type 2 diabetes (T2D). Novel, general applicable biomarkers are therefore needed. MicroRNAs (miRNAs) are secreted into the circulation from cells of various tissues proportional to local disease severity. Serum miRNA classifiers including miR-550a-5p were recently found to discriminate T2D women without and with prevalent fragility fractures with high specificity and sensitivity (AUC&#6...

ba0005oc5.2 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

Impaired bone material properties increase the risk of all fractures and severity of vertebral fractures in osteoporosis: an impact microindentation study

Sosa Daysi Duarte , Eriksen Erik Fink

Context: Previous impact microindentation studies have demonstrated that osteoporosis patients exhibit impaired bone material strength, which may contribute to skeletal fragility. Whether the impact differs between subtypes of fractures has, however, not been evaluated yet.Objective: To test whether impaired bone material properties differ between different subtypes of osteoporotic fracture and assess how this property relates to fracture severity.<p...

ba0005oc5.3 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

Osteoprotegerin autoantibodies are independently associated with low hip bone mineral density and increased fracture risk in patients with ankylosing spondylitis

Hauser Barbara , Zhao Sizheng , Visconti Micaela R , Riches Philip L , Goodson Nicola J , Ralston Stuart H

Osteoporosis and vertebral fractures are recognised complications of ankylosing spondylitis (AS) but the underlying causes are incompletely understood. Osteoprotegerin (OPG) is a decoy receptor for RANK-L and inhibits osteoclastogenesis. We have previously demonstrated that antibodies to OPG (OPG-Ab) are associated with osteoporosis and increased bone turnover in patients with autoimmune diseases. The aim of this study was to determine whether OPG-Abs were detectable in AS pat...

ba0005oc5.4 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

Fine mapping of the chromosome 1p13 locus for susceptibility to Paget's disease of bone

Abdullah Fawaaz , Jin Huilin , Wani Sachin , Albagha Omar , Ralston Stuart

Introduction: Paget’s disease of bone (PDB) is a common disorder characterised by increased and disorganised bone remodelling. Previous genome wide association studies identified a locus for susceptibility to PDB on chromosome 1p13, tagged by rs484959 which lies 87 kb upstream of the CSF1 gene. This is a strong candidate for PDB since it encodes macrophage colony-stimulating factor (M-CSF) a critical cytokine for osteoclast formation and survival.Pu...

ba0005oc5.5 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

The relationship between muscle strength and bone outcomes in ageing UK men

Zengin Ayse , Pye Stephen R , Cook Michael J , Adams Judith E , Wu Frederick C W , O'Neill Terrence W , Ward Kate A

Morbidity and mortality are associated with osteoporosis and sarcopenia. There are few data describing the associations between functional measures of muscle and bone. Therefore, the aim of this study was to examine the associations of muscle strength and tibial bone outcomes in ageing men.Men (n=301) aged 40–85 years were recruited in UK (201-White, 43-Black, 57-South-Asian). pQCT was performed at the 38 and 66% tibia with the outcome meas...

ba0005oc5.6 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

The metabolic alterations behind bone fragility in Duchenne muscular dystrophy

Broggi Francesca , Vai Silvia , Maggi Lorenzo , Gorni Ksenija , D'Angelo Grazia , Pane Marika , Bianchi Maria Luisa

Low bone mineral density (BMD) and an increased rate of both peripheral and vertebral fractures have been observed in patients with Duchenne muscular dystrophy (DMD), but studies on bone metabolic alterations in this disease are still very few.We are now presenting the preliminary findings of an ongoing multicenter, prospective study aimed to identify the characteristics of DMD boys carrying a higher risk of bone loss and fractures, through the evaluatio...