Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p269 | Muscle, physical activity and bone | ECTS2016

Effects of inorganic phosphate and FGF23 on C2C12 myoblast cells

Raimann Adalbert , Dangl Alexander , Javanmardi Alireza , Ertl Alexandra , Egerbacher Monika , Greber-Platzer Susanne , Haeusler Gabriele

Background: Disturbance of systemic phosphate homeostasis is often associated with musculoskeletal dysfunction. Multiple factors related to the underlying condition such as calcium levels and endocrine mechanisms are thought to contribute. Distinct effects of inorganic phosphate itself as well as its main regulator FGF23 by activation of similar pathways have been shown in several cell types. We are not aware of any detailed investigations into their effect on the differentiat...