Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p95 | (1) | ICCBH2019

Detection of intact FGF23 using a novel well-characterized ELISA

Wallwitz Jacqueline , Gadermaier Elisabeth , Bitzer Annegret , Himmler Gottfried

Objectives: Fibroblast growth factor 23 (FGF23) is a bone-derived phosphaturic hormone. The main target organ is the kidney, where FGF23 suppresses renal phosphate reabsorption and vitamin D synthesis. It also stimulates calcium reabsorption in the kidney. FGF23 secretion is stimulated by 1,25(OH)2D and by increased extracellular phosphate concentration, thus forming a feedback loop between kidney and bone. The bioactive intact FGF23 contains 251 amino acids and is glycosylate...