Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p15 | (1) | ICCBH2019

TA-46 prevents premature synchondrosis and restores foramen magnum size in a mouse model of achondroplasia

Garcia Stephanie , Rignol Guylene , Goncalves Diogo , Dellugat Pierre , Tosello Lionel , Marsault Raphael , Stavenhagen Jeff , Santarelli Luca , Gouze Elvire

Objectives: Achondroplasia, the most common form of short limb dwarfism, is a rare genetic disorder caused by a gain-of-function mutation of the FGFR3 receptor (FGFR3-G380R) and there are currently no effective treatments available. We have developed TA-46, a recombinant human soluble FGFR3(sFGFR3) form of the FGFR3 cell surface receptor containing an extra-cellular ligand-binding domain, including three IgG domains, which confer binding specificity. TA-46 is designed to block...