Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp13 | Arthritis and other joint diseases: translational and clinical | ECTS2013

Clinical and histomorphometrical assessment of bone quality in hip osteoarthritis and osteoporosis

Feola Maurizio , Rao Cecilia , Celi Monica , Gasbarra Elena , Tarantino Umberto

Osteoarthritis (OA) and osteoporosis (OP) are two diseases characterized by the alteration of bone quality, that affect mainly elderly people reducing their quality of life. Although an inverse relationship between has been shown by some studies, other reports supported the co-existence of these pathologies. In this study we combined clinical and structural features to clarify the relationship between OA and OP.Among all the patients who underwent a tota...

ba0001pp188 | Cell biology: osteoblasts and bone formation | ECTS2013

Intracellular calcium fluxes in human bone cells in osteoporotic and osteoarthritic patients

celi Monica , Gasbarra Elena , Frank Claudio , Cutarelli Alessandro , Cinci Giulio Fioravanti , Tarantino Umberto

We studied changes in intracellular Ca2+ concentration in bone cell cultures obtained from human subjects with osteoporosis and osteoarthritis, to evaluate differences between these patients and healthy subjects. We enrolled 36 patients: 12 undergoing primary total hip arthroplasty for osteoporotic femoral fractures (group A, mean age range 57–80), 12 for hip osteoarthritis (group B, mean age range 57–80), and 12 healthy subjects who suffered a high-energy...

ba0005p461 | Other diseases of bone and mineral metabolism | ECTS2016

The role of bone morphogenetic proteins in muscle regeneration of osteoarthritic patients

Iundusi Riccardo , Gasbarra Elena , Scimeca Manuel , Pignatale Ilaria , Bonanno Elena , Tarantino Umberto

Introduction: Age-related bone diseases, such as osteoarthritis (OA) and osteoporosis (OP), are strongly associated with sarcopenia and muscle fiber atrophy. Potential mechanisms involved in the reduction of skeletal muscle mass during sarcopenia converge on the failure of satellite cells in replacing and repairing damaged muscle fibers. Myostatin and bone morphogenetic proteins (BMPs) are molecules able to regulate muscle mass homeostasis by activating satellite stem cells [4...

ba0001pp359 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Ten years of increasing hip fractures incidence in Italy but first good news from the Analysis of National Hospitalizations Records 2000–2009

Piscitelli Prisco , Feola Maurizio , Rao Cecilia , Celi Monica , Piccirilli Eleonora , Gasbarra Elena , Parri Simone , Iolascon Giovanni , Maria Luisa Brandi , Tarantino Umberto

Objectives: We aimed to evaluate hospitalization rate of femoral neck fractures in the elderly Italian population over ten years.Methods: We analyzed national hospitalizations records collected at central level by Ministry of Health from 2000 to 2009. Age- and sex-specific rates of fractures occurred at femoral neck in people ≥65 years old. We performed a sub-analysis over a 3-year period (2007–2009), presenting data per five-year age groups, ...