Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p243 | Genetics and Epigenetics | ECTS2016

Geometric morphometrics: a mathematical tool to compare morphological traits based on SOST dysfunction in mice

Schwarze Uwe Yacine , Dobsak Toni , Gruber Reinhard , Bookstein Fred L

Introduction: Genetic disorders are usually characterised by subjective morphological traits. Mouse models should represent the human situation but it is difficult to translate morphology traits from one species to another. Thus, there is a demand to objectively assess morphological traits. Geometric morphometrics is a mathematical tool to evaluate morphology based on normalised three-dimensional coordinates. Here we use geometric morphometrics to compare the morphology of <em...

ba0003pp143 | Cell biology: osteoblasts and bone formation | ECTS2014

Utilization of L-mimosine in pulp regeneration: lessons from cell culture and tooth slice organ cultures

Muller Heinz-Dieter , Trimmel Katharina , Cvikl Barbara , Gruber Reinhard , Agis Hermann

After trauma or carious lesion dental pulp healing is difficult to predict. In addition systemic diseases like diabetes mellitus can impair the regenerative capacity. New regenerative strategies target prolyl hydroxylase (PHD) by pharmacological inhibitors to stimulate hard and soft tissue healing. PHD inhibitors such as L-mimosine (L-MIM) induce vascular endothelial growth factor (VEGF) production by promoting angiogenesis. However, it is unclear if L-MIM is a feasible tool t...