Searchable abstracts of presentations at key conferences on calcified tissues

ba0007lb2 | (1) | ICCBH2019

Lumbar spine quantitative computed tomography (QCT) is a better predictor of vertebral fracture in boys with Duchenne muscular dystrophy (DMD) than either DXA or peripheral QCT

Crabtree Nicola , Machin Michael , Padidela Raja , Kariki Eleni , Hughes Imelda , Shaw Nick , Mughal Zulf

Objectives: Vertebral fractures are common in boys with DMD taking daily corticosteroids. Treatment is usually initiated when vertebral fractures have been identified. However, prophylactic treatment may be possible if reliable risk factors for vertebral fracture can be identified. The aim of this work was to compare the diagnostic accuracy of three different bone strength assessment techniques in a cohort of DMD boys.Methods: Thirty-three boys with DMD ...

ba0004op9 | (1) | ICCBH2015

Growth, body mass index, bone health and ambulatory status of boys with Duchenne Muscular Dystrophy treated with daily vs intermittent oral glucocorticoid regimen

Crabtree Nicola , Padidela Raja , Shaw Nicholas , Hogler Wolfgang , Roper Helen , Hughes Imelda , Adams Judith , Daniel Anjali , Mughal Zulf

Background: Oral glucocorticoids (GC; prednisolone dose of 0.75 mg/kg per day), help to preserve muscle strength and prolong independent walking in boys with DMD. This study compared longitudinal growth, body mass index (BMI), bone mineral density (BMD), vertebral fractures (VFs) and ambulatory status in boys with DMD on daily (DAILY) or intermittent (INTER; 10 days on & 10 days off), oral GC regimens.Methods: 50 DMD boys from two UK centres were inc...