Searchable abstracts of presentations at key conferences on calcified tissues

ba0004oc6 | (1) | ICCBH2015

Early life motor control is positively associated with adolescent bone strength

Ireland Alex , Sayers Adrian , Deere Kevin , Emond Alan , Tobias Jon

Recent evidence supports a strong influence of early life movement on infant bone strength. However, it is not known whether early motor development also influences bone strength in later life. Therefore, we examined relationships between locomotor score (using components of the Denver Developmental Screening Test) at 18 months, and the Avon Longitudinal Study of Parents and Children (ALSPAC) Co-ordination Test (ACT) score at 7 years, and bone outcomes as measured at age 17 ye...

ba0006p097 | (1) | ICCBH2017

Evaluation of the use of body quantitative computed tomography for the assessment of the tibia in children with Neurofibromatosis 1

Ireland Alex , Mughal Zulf , Adams Judith , Brown Keenan , Eelloo Judith , Ward Kate

Assessment of metaphyseal bone growth in children by peripheral quantitative computed tomography (pQCT) is limited by use of a thin (2.3 mm) 2D slice to represent the ~20 mm metaphyseal region within which there is substantial local variation in bone properties (Marjanovic et al., 2009). In addition, scan positioning is performed by manual visual growth plate identification from which a region located proximal to the growth plate at 4% of tibia leng...

ba0006lb8 | (1) | ICCBH2017

Breech presentation is associated with neonatal and early childhood deficits in bone mass and size

Ireland Alex , Crozier Sarah , Heazell Alexander , Ward Kate , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Animal studies suggest that fetal movements are key to healthy skeletal development, but evidence in humans is limited. Breech presentation occurs in 3% of term births and is associated with reduced fetal movement and higher incidence of hip dysplasias, but more general effects on bone development have not been explored.Offspring whole body bone outcomes were measured using dual-energy X-ray absorptiometry (DXA) at mean(SD) 6(5) days after birth in 993 i...

ba0007p163 | (1) | ICCBH2019

Prenatal oligohydramnios is associated with hip shape in adolescent males

Tobias Jon , Frysz Monika , Lawlor Debbie , Aspden Richard , Gregory Jennifer , Ireland Alex

Hip development is influenced by mechanical loading during fetal movement by joint and reaction forces equivalent to several times bodyweight. These forces increase with fetal size and gestation length, and are lower in oligohydramnios and breech presentation which are both risk factors for developmental hip disorders. However, associations between indicators of prenatal mechanical loading and hip shape in later life remain unexplored. We therefore examined associations betwee...