Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p24 | (1) | ICCBH2019

The role of the RACK1-c-Src axis in regulation of osteoclast function

Park Jin Hee , Jeong Eutteum , Lee Soo Young

Activation of p38 MAPK by RANKL is regulated by the scaffolding protein receptor for activated C-kinase 1 (RACK1) in osteoclast precursors, whereas it is unclear whether RACK1 can also affect in mature osteoclasts. In this study, to identify that the interaction of RACK1 with c-Src is essential for osteoclast function, we generated several mutants affecting the RACK1-c-Src association. A RACK1 mutant protein (mutations of tyrosine 228 and 246 residues to phenylalanine) disrupt...