Searchable abstracts of presentations at key conferences on calcified tissues

ba0007is11 | (1) | ICCBH2019

Clock genes and bone and mineral regulation

Kawai Masanobu

The circadian clock network is an evolutionally conserved system by which organisms adapt their metabolic activities to the environmental inputs including the availability of nutrients. The master pacemaker of circadian clock system is located in the suprachiasmatic nucleus (SCN) and is well known to play pivotal roles in metabolic regulations including skeletal and mineral metabolisms. In addition to the central pacemaker, peripheral tissues also possess its own circadian sys...

ba0006lb5 | (1) | ICCBH2017

Role of type III sodium/phosphate co-transporters in the responsiveness of osteoblasts to extracellular inorganic phosphate

Michigami Toshimi , Yamazaki Miwa , Kawai Masanobu , Ozono Keiichi

Objectives: As osteoblasts mature, they acquire the expression of multiple molecules involved in phosphate metabolism, including dentin matrix protein 1 (DMP1) and fibroblast growth factor 23 (FGF23). This suggests that osteoblasts and osteocytes may sense and respond to alterations in the phosphate availability in their microenvironment. We previously reported that increased extracellular inorganic phosphate (Pi) triggered signal transduction in various cell types to alter ge...

ba0007p114 | (1) | ICCBH2019

Hypophosphatasia in Japan: ALPL mutation analysis in 98 patients

Michigami Toshimi , Tachikawa Kanako , Yamazaki Miwa , Kawai Masanobu , Kubota Takuo , Ozono Keiichi

Background: Hypophosphatasia (HPP) is caused by inactivating mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). HPP is variable in clinical manifestations and prognosis, and is generally classified into six subtypes: perinatal lethal, perinatal benign (prenatal benign), infantile, childhood, adult, and odonto HPP. Although genetic test is broadly used for diagnosis of HPP, the genotype-phenotype relationship still remains unclear.<p class...