Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p45 | Bone development/growth and fracture repair | ECTS2016

Mast cells regulate inflammation and bone regeneration in fracture healing

Kroner Jochen , Kovtun Anna , Messmann Joanna , Strauss Gudrun , Seitz Sebastian , Schinke Thorsten , Dudeck Anne , Ignatius Anita

Mast cells (MCs) are pro-inflammatory sensor and effector cells of the immune system. MCs seem to play a role in bone metabolism, because patients with systemic mastocytosis develop osteoporosis. MCs are present in the fracture callus during bone healing, however, their function has not yet been investigated. Here, we examined the role of MCs in the inflammatory and repair phase during fracture healing.Male 12-week old MC deficient mice (Mcpt5-Cre R-DTA)...

ba0005p54 | Bone development/growth and fracture repair | ECTS2016

Role of interleukin-6 in the early and late fracture healing phase

Prystaz Katja , Kovtun Anna , Kaiser Kathrin , Heidler Verena , Kroner Jochen , Haffner-Luntzer Melanie , Ignatius Anita

Interleukin-6 (IL-6) plays an important role in bone metabolism and regulates fracture healing in a presently unknown process. In the fracture callus IL-6 expression is biphasic; it peaks during the inflammatory phase and again during intramembranous and endochondral ossification (Ai-Aql et al. 2008). Few studies using IL-6 knockout mice indicate that IL-6 might be crucial for bone healing (Yang et al. 2007). However, a generalized IL-6 knockout induces multi...