Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp226 | Osteoporosis: evaluation and imaging | ECTS2014

Combining BINDEX and FRAX in treatment decision pathway for osteoporosis

Karjalainen Janne , Riekkinen Ossi , Kroger Heikki

Objective: According to National Osteoporosis Foundation (NOF) guidelines, treatment is recommended for osteoporotic patients and patients with osteopenia and high fracture probability (FRAX with BMD over 3% for hip and/or over 20% for other fractures). In this study, a pocket size pulse-echo (PE) ultrasound (US) device and FRAX with BMI is used in treatment pathway analysis and compared to NOF guidelines.Materials and methods: Elderly Caucasian woman (<...

ba0004p124 | (1) | ICCBH2015

Bisphosphonate treatment and the characteristics of femoral fractures in children with osteogenesis imperfecta

Vuorimies Ilkka , Mayranpaa Mervi , Valta Helena , Kroger Heikki , Toiviainen-Salo Sanna , Makitie Outi

Objective: Bisphosphonates (BPs) are widely used in treatment of pediatric patients with osteogenesis imperfecta (OI) and their beneficial effect on bone density and fracture rates has been well reported. Atypical femoral fracture is a potential complication of bisphosphonates, usually occurring after several years of BP treatment in postmenopausal women. Some evidence suggests increased proportion of subtrochanteric femoral fractures in children with OI after prolonged use of...

ba0006oc14 | (1) | ICCBH2017

Body composition and associated biomarkers as determinants of bone mineral density in children 6–8 years of age – The Physical Activity and Nutrition in Children (PANIC) study

Soininen Sonja , Sidoroff Virpi , Lindi Virpi , Mahonen Anitta , Kroger Liisa , Kroger Heikki , Jaaskelainen Jarmo , Atalay Mustafa , Laaksonen David , Laitinen Tomi , Lakka Timo A.

Background and objectives: Lean mass (LM) has been positively associated with bone mineral density (BMD), but the impact of increased adiposity on bone especially in children is controversial. Several biomarkers, secreted by adipose tissue, skeletal muscle, or bone, may have important roles in the bone health. Our aim was to study the association of body composition, adipokines, myokines, inflammation-related cytokines, growth factors, and serum 25-hydroxyvitamin D (S-25(OH)D)...

ba0002lb2 | (1) | ICCBH2013

WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta identify a key WNT ligand regulating bone mass

Laine Christine , Joeng Kyu Sang , Campeau Philippe , Kiviranta Riku , Tarkkonen Kati , Grover Monica , Lu James , Pekkinen Minna , Wessman Maija , Heino Terhi , Nieminen-Pihala Vappu , Laine Tero , Kroger Heikki , Cole William , Lehesjoki Anna-Elina , Krakow Deborah , Curry Cynthia , Cohn Daniel , Gibbs Richard , Lee Brendan , Makitie Outi

The role of the WNT pathway in skeletal maintenance has been extensively studied since the identification of mutations in key signaling WNT mediators (LRP5 and sclerostin) in high and low bone mass phenotypes. However, the identity of the key WNT ligand that signals via LRP5/6 has remained unknown. We aimed to identify genes with a major effect on the skeleton by studying individuals and families with early-onset osteoporosis or osteogenesis imperfecta (OI).<p class="abste...