Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp351 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Cytokine levels in the bone marrow are not just a reflection of the levels in serum: suggesting that bone marrow constitutes an independent compartment

Harslof Torben , Sorensen Lotte , Pedersen Steen , Langdahl Bente

Bone marrow is composed of cells developed within the marrow compartment as well as blood supplied from the general circulation. Bone tissue is affected by cytokines within the bone marrow.We investigated if the levels of different bone acting cytokines differ between bone marrow and blood from the peripheral circulation.Fifty-three healthy postmenopausal women participated in a study designed to evaluate the effect of rosiglitazon...

ba0003pp189 | Genetics | ECTS2014

A polymorphism in the TGF-β1 gene affects TGF-β1 secretion

Husted Lise , Sorensen Lotte , Stenkjaer Liselotte , Langdahl Bente

Transforming growth factor (TGF)-β1 is the most abundant growth factor in human bone. Several polymorphisms have been described in the TGF-β1 gene (TGFB1). We have previously shown that individuals with the CC genotype of the T29C polymorphism have higher bone mass at the femoral neck. The T29C polymorphism causes a change from leucine to proline at codon 10, which is located in the hydrophobic α-helical part of the signal peptide....

ba0003pp195 | Genetics | ECTS2014

Interactions between the effects of polymorphisms in the RANK and RANKL genes affects bone mass

Andersen Jane Dahl , Harslof Torben , Husted Lise , Langdahl Bente

Osteoporosis is a common disorder with a partly genetic pathogenesis. Interaction between RANKL and its receptor RANK is essential in bone remodeling.We therefore investigated the effect of polymorphisms in the RANK and RANKL genes and interaction between the effects on bone mineral density (BMD) and vertebral fractures.The study was a case-control study with 462 osteoporotic patients and 336 controls. Ten polymor...

ba0003lb3 | (1) | ECTS2014

Meta-analysis of randomised trials shows limited evidence to support the use of bisphosphonates for fracture prevention in osteogenesis imperfecta

Hald Jannie , Langdahl Bente , Evangelou Evangelos , Ralston Stuart

Osteogenesis imperfecta refers to a group of inherited disorders characterised by increased bone fragility, low bone mass and fragility fractures. Most patients carry mutations in the genes that encode type I collagen or other proteins involved in its post-translational modification. Bisphosphonates are widely used in the treatment of osteogenesis imperfecta but clinical trials have been powered to detect effects on BMD rather than fracture. In order to gain better understandi...

ba0005oc1.3 | Clinical trials and osteoporosis treatment | ECTS2016

Treatment with vitamin MK-7 prevents deterioration of trabecular bone

Roenn Sofie Hertz , Harsloef Torben , Pedersen Steen Boenloekke , Langdahl Bente Lomholt

Background: Clinical studies suggest that vitamin K2 prevents bone loss and may protect against fractures. Vitamin K is a cofactor in the carboxylation of Osteocalcin (OC). Carboxylated OC promotes mineralization of bone. The aim of the study was to investigate the effect of vitamin K2 on osteocalcin, bone mass and -quality.Methods: We conducted a randomized placebo-controlled double-blinded clinical trial, in which 142 postmenopausal osteopenic women we...

ba0005oc3.3 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Vitamin D supplementation reduces pregnancy chances: a randomized, placebo-controlled trial

Rasmussen Gitte Bloch , Mosekilde Leif , Vestergaard Peter , Heickendorff Lene , Ulbjerg Niels , Langdahl Bente , Rejnmark Lars

Introduction: Low 25-hydroxyvitamin D (25OHD) levels are frequently found in fertile women and associated with low birth weight, reduced fertility and adverse pregnancy outcomes.Objective: We investigated the effects of vitamin D supplementation on birth weight, fertility, and delivery complications in women planning pregnancy with low 25OHD levels.Methods: This was an investigator-initiated double-blind, randomized, placebo-contro...

ba0005p389 | Osteoporosis: treatment | ECTS2016

Hypercalcemia after discontinuation of long-term denosumab treatment

Langdahl Bente , Harslof Torben , Kaal Andreas , Rejnmark Lars , Sophie Solling Anne

Purpose: Denosumab is commonly used as an anti-resorptive agent to treat osteoporosis. After discontinuation of denosumab, however, bone resorption increases again, and the bone mass gained during therapy is lost within a year.Methods: We present a case report of asymptomatic hypoparathyroid hypercalcemia in a patient who discontinued long-term treatment with denosumab.Results: A 67-year old women with osteoporosis was treated with...

ba0005p393 | Osteoporosis: treatment | ECTS2016

Long-term high-dose resveratrol supplementation reduces bone mass and strength in rats

Juul Ornstrup Marie , Bruel Annemarie , Skovhus Thomsen Jesper , Harslof Torben , Lomholt Langdahl Bente , Bonlokke Pedersen Steen

Background: Resveratrol (RSV), a natural polyphenolic compound, stimulates osteoblasts and inhibits osteoclast activation in vitro. Conflicting results have emerged from short-term studies in rodents but a recent study in men suggests a positive effect on BMD.Aim: To evaluate effects of short- and long-term high-dose RSV supplementation on bone in immobilized and non-immobilized rats.Methods: A total of 72 female Wistar ra...

ba0005p436 | Other diseases of bone and mineral metabolism | ECTS2016

Determinants of health related quality of life in adults with osteogenesis imperfecta

Hald Jannie Dahl , Folkestad Lars , Harslof Torben , Brixen Kim , Langdahl Bente

Osteogenesis imperfecta (OI) is a systemic connective tissue caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various degrees of growth deficiency and bone deformity. Other symptoms are early hearing loss, abnormal dental tissue and hypermobility. It is not known whether the systemic effect of a defect collagen type 1 influences the quality of life in people with OI. We aimed to investigate health related quality of life...