Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp46 | Bone biomechanics and quality | ECTS2013

Low magnitude vibration signals attenuate the rapid bone mass induced by lipopolysaccharide

Kim In Sook , Cho Tae Hyung , Lee Beomseok , Hwang Soon Jung

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

ba0005p156 | Cell biology: osteoblasts and bone formation | ECTS2016

The differential effects of zoledronate and etidronate on the in vivo early osseous healing process of an extracted socket and a tibial defect

Kim In Sook , Lim Shin Saeng , Lee Beomseok , Hwang Soon Jung

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...

ba0001pp487 | Other diseases of bone and mineral metabolism | ECTS2013

Preliminary study for the effect of PDGF or mesenchymal stem cells on tissue repair of cutaneous radiation injury

Hwang Soon Jung , Cho Tae Hyung , Lee Beomseok , Oh Ji Hye , Kim In Sook

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...