Searchable abstracts of presentations at key conferences on calcified tissues

ba0005cabs.oc2.4 | Oral Communications | ECTS2016

Peripheral tumour re-growth following combination therapy – role of the bone microenvironment

Haider Marie-Therese , Ottewell Penelope D. , Brown Nicola J. , Lefley Diane V. , Holen Ingunn

Background: Cancer patients often receive a combination of drugs that target both the microenvironment and the tumour cells. However, the role of the bone microenvironment (BME) in mediating peripheral breast cancer growth remains poorly understood. This is the first study to determine whether reduced subcutaneous tumour growth following combination therapy is due to direct interactions between the drugs and tumour cells or through zoledronic acid induced alterations to the BM...

ba0007oc18 | (1) | ICCBH2019

Developing a human-mouse hybrid model of osteogenesis imperfecta for investigating new therapies for children

Arshad Fawaz , Lefley Diane , Madan Sanjeev , Fernandes James , Bishop Nick , Ottewell Penelope

Objectives: Osteogenesis imperfecta (OI) displays a heterozygous phenotype even amongst similar genotypes. It has therefore been difficult to establish a mouse model which represents clinical OI in children. By engrafting human OI bone into mice we have developed a hybrid model enabling us to investigate the efficacy of new treatments for this phenotypically diverse condition.Methods: Bone chips, that would otherwise be discarded, were collected from chi...

ba0007p133 | (1) | ICCBH2019

Losartan reduces circulating TGFb and CTX and increases vertebral bone mass in the OIM mouse

Bishop Nick , Kalajzic Ivo , Arshad Fawaz , Lefley Diane , Gossiel Fatma , Ottewell Penny

Objectives: Losartan is an angiotensin II receptor type 1 (AT1) antagonist. Losartan reduces circulating TGFb concentrations in a variety of myopathic models. We hypothesised that losartan administration to the murine osteogenesis imperfecta model OIM would result in lower circulating TGFb and CTX (bone resorption marker) and increase bone mass.Methods: All procedures were approved by UConn Health Institutional Animal Care and Use Committee and performed...