Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp81 | Bone development/growth and fracture repair | ECTS2013

Characterization of an Y1R antagonist as a drug for bone regeneration

Alencastre Ines , Almeida Catarina , Leite Diana , Alves Cecilia , Sousa Daniela , Neto Estrela , Lamghari Meriem

Recently, Y1 receptor (Y1R) has arisen as a potential regulator in the local control of bone turnover. BIBP3226 is a potent Y1R selective antagonist that was successfully used in in vitro studies showing a positive impact in the benefit of bone turnover, thus providing good perspectives for its use as a pharmacological tool for bone regeneration.However, BIBP3226 behaviour in a complex milieu such as the bone compartment is unknown. As drugs can...