Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p63 | (1) | ICCBH2019

Bone geometry and microarchitecture deficits in children with Alagille syndrome

Kindler Joseph , Mitchell Ellen , Piccoli David , Grimberg Adda , Leonard Mary , Loomes Kathleen , Zemel Babette

Objectives: Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture, but the etiology of this disposition is unknown. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS.Methods: This was a cross-sectional study of 10 children (9 females) ages 8-18 years, with a clinical diagnosis of ALG...