Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p42 | (1) | ICCBH2019

FGF 23 measurements in children with fibrous dysplasia: useful or not?

Huma Zilla , Mackinnon Natasha , Aston Will , Pollock Rob

Fibrous dysplasia is a mosaic disease resulting from post-zygotic activating mutations of the GNAS locus which codes for the α subunit of the Gs G-coupled protein receptor. In bone, impaired signalling results in impaired differentiation and proliferation of bone marrow stromal cells which are replaced by fibrous tissue resulting in bone fragility and dysplasia. All children diagnosed with Fibrous Dysplasia at The Royal National Orthopaedic Hospital since 2009 (103 childr...