Searchable abstracts of presentations at key conferences on calcified tissues

ba0003oc3.5 | Osteoclasts, gastric hormones and HIF | ECTS2014

Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical microarchitectures and bone strength.

Mieczkowska Aleksandra , Mansur Sity , Flatt Peter , Irwin Nigel , Chappard Daniel , Mabilleau Guillaume

Objectives: A role for the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in controlling bone mass and strength has previously been reported. However, lack of one gut hormone is compensated by an elevated sensitivity to the other in single receptor knockout mice. As such the exact role of GIP and GLP-1 in bone is unclear. The aims of the present study were to assess bone mass and strength in mice with functional deletion of ...