Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p8 | (1) | ICCBH2019

Polyhydramnios: sole risk factor for non-traumatic fractures in two infants

Nadeau Genevieve , Olivier Patricia , Fiscaletti Melissa , Campeau Philippe , Alos Nathalie

Bone loading is a primary determinant of bone strength in later childhood and adulthood. Our understanding of how mechanical stimuli generated by foetal kicking and movements impact skeletal development is still limited. Many studies suggest that a sufficient and balanced supply of energy, proteins, vitamins, calcium, phosphorus, and other nutrients is an essential prerequisite for normal bone development. However, only few studies highlight the contribution of the biomechanic...

ba0007p134 | (1) | ICCBH2019

First report of skin reaction with Zoledronic Acid

Olivier Patricia , Fiscaletti Melissa , Desroches Anne , Alos Nathalie

Adverse reactions to bisphosphonates are common and thus, most of them are predictable side effects to the drug. Allergic reactions or skin reactions of any type or severity associated with bisphosphonates have been scarcely described in the literature. Allergic and skin reactions to bisphosphonates have been estimated to occur in less than 1% of patients. The mechanism of these reactions is unknown, although it is presumed to be IgE mediated. All of the bisphosphonates share ...

ba0006p113 | (1) | ICCBH2017

A challenging case of hyperphosphatemic tumoral calcinosis

Ribault Virginie , Campeau Philippe M. , Laberge-Malo Marie , Olivier Patricia , Nyalendo Carine , Alos Nathalie

: Hyperphosphatemic tumoral calcinosis (HTC) is a rare autosomal recessive metabolic disorder characterized by ectopic calcifications due to progressive deposition of basic calcium phosphate crystals in soft tissues. The biochemical hallmark of HTC is hyperphosphatemia caused by increased renal absorption of phosphate due to loss-of-function mutations in three genes: in the fibroblast growth factor-23 gene (FGF23) coding for a potent phosphaturic protein, in GALNT3, g...