Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p60 | (1) | ICCBH2019

FGF23-expressing osteocytes are confined to bone packets that completed primary mineralization in patients with chronic kidney disease on dialysis (CKD5D)

Fratzl-Zelman Nadja , Pereira Renata C , Roschger Paul , Salusky Isidro B , Klaushofer Klaus , Wesseling-Perry Katherine

Objectives: FGF23 is expressed in clusters of osteocytes at the trabecular periphery suggesting that FGF23-expressing osteocytes are confined to specific basic multicellular units (BMUs) at the trabecular surface. Higher numbers of FGF23-expressing osteocytes are found in chronic kidney disease (CKD) patients with preserved skeletal mineralization indices. We thus combined immunohistochemistry and quantitative backscattered electron imaging (qBEI) to explore the hypothesis tha...

ba0006p070 | (1) | ICCBH2017

The abnormally high and heterogeneous bone matrix mineralization after childhood solid organ transplantation is not further increased by bisphosphonate treatment

Fratzl-Zelman Nadja , Valta Helena , Pereira Renata C , Misof Barbara M , Roschger Paul , Jalanko Hannu , Wesseling-Perry Kathrine , Klaushofer Klaus , Makitie Outi

Background: Chronic renal, liver and heart failure in children associate with multiple skeletal complications. Increased fracture incidence often persists after transplantation and might be related to alterations in bone material properties. Moreover, it is not clear whether bisphosphonate therapy (BP) alters bone matrix mineralization in these patients.Methods: In the present study we evaluated bone mineralization density distribution (BMDD) by quantita...