Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp74 | Bone development/growth and fracture repair | ECTS2013

Metaphyseal fracture healing in a sheep model of low turnover osteoporosis induced by hypothalamic–pituitary disconnection

Bindl Ronny , Oheim Ralf , Pogoda Pia , Beil Frank Timo , Gruchenberg Katharina , Reitmaier Sandra , Wehner Tim , Calcia Enrico , Radermacher Peter , Claes Lutz , Amling Michael , Ignatius Anita

We recently established a large animal model of osteoporosis in sheep using hypothalamic┬ľpituitary disconnection (HPD). As central regulation is important for bone metabolism, HPD-sheep developed severe osteoporosis because of low bone turnover. In this study we investigated metaphyseal fracture healing in HPD-sheep. To elucidate potential pathomechanisms, we included a treatment group receiving thyroxine (T4) and 17╬▓-estradiol. Because clinically osteopor...