Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc1.2 | Osteoporosis epidemiology and long term treatment complications | ECTS2013

Hip fractures and bone mineral density of the elderly: importance of serum 25-hydroxy vitamin D

Steingrimsdottir Laufey , Halldorsson Thorhallur , Siggeirsdottir Kristin , Cotch Mary Frances , Eiriksdottir Gudny , Sigurdsson Sigurdur , Harris Tamara , Gudnason Vilmundur , Sigurdsson Gunnar

Introduction: Vitamin D is known to be important for bone health. Still, the significance of serum 25-hydroxy vitamin D concentrations (s-25OHD) for hip fracture risk of the elderly is uncertain. Discordant findings may in part be explained by difficulties of RCTs or large cohort studies to reach both the frail and the healthy elderly. The objectives of this study were to determine the risk of hip fractures of the elderly related to s-25OHD, including both the frail and the he...

ba0003pp222 | Osteoporosis: evaluation and imaging | ECTS2014

Association of CT-based finite element estimates of femur strength with fracture status in three clinical studies on post-menopausal women

Schileo Enrico , Falcinelli Cristina , Balistreri Luca , Henys Petr , Baruffaldi Fabio , Sigurdsson Sigurdur , Gudnason Vilmundur , Boutroy Stephanie , Taddei Fulvia

Introduction: The first clinical applications of FE-strength estimates to classify osteoporotic fractures showed inhomogeneous results. We developed a FE model that correlated well with femur strength in-vitro (R2=0.9, 14 femurs). This work aims to verify if our model can classify osteoporotic fractures in three case-control studies: a retrospective and a prospective study on proximal femur fracture, and a retrospective study on prevalent ...

ba0001pp387 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Sclerostin associated with vertebral bone marrow fat in older men but not women

Ma Vivian , Li Xiaojuan , Sigurdsson Sigurdur , Eriksdottir Gudny , Hauksdottir Alda , Palermo Lisa , Hue Trisha , Lang Thomas , Harris Tamara , Rosen Clifford , Vittinghoff Eric , Siggeirsdottir Kristin , Sigurdsson Gunnar , Oskarsdottir Diana , Gudnason Vilmundur , Schwartz Ann

Previous studies found a negative correlation between vertebral bone marrow fat (MF) and bone density (BMD). Proposed mechanisms for this include i) a shift in stem cell lineage allocation from osteoblasts towards adipocytes, and ii) an increase in osteoclast-promoting cytokines with greater MF. However, little is known about the relationship between MF and bone markers. To assess these relationships in older adults, we used data from the AGES-Reykjavik cohort. MF was measured...