Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc6.3 | Mineralisation and energy metabolism | ECTS2013

Collagen XV as a bone matrix organizer

Vicente David , Finnila Mikko , Izzi Valerio , Koivunen Jarkko , Pihlajaniemi Taina

Collagen XV is a secreted proteoglycan localized in the outermost layer of the basement membrane and in the fibrillar matrix. Previously, the collagen XV gene (COL15A1) has been linked to osteogenic differentiation, being identified mainly in mature osteoblasts forming new bone tissue or lining bone trabeculae. Our previous data on collagen XV knockout fetuses reports subtle skeletal changes. The aim of this study was to analyse skeletal changes in adult mice lacking collagen ...