Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp59 | Bone development/growth and fracture repair | ECTS2013

The effect of mTORC1 on postnatal skeletal development

Matthews Mary , Zannettino Andrew , Fitter Stephen , Martin Sally

Mammalian target of rapamycin (mTOR) is a serine–threonine kinase that plays a central role in a number of key cellular pathways that have been previously implicated in bone formation. mTOR mediates these diverse roles by forming two multi-protein complexes, mTORC1 and mTORC2, each of which is defined by unique proteins raptor and rictor respectively.Studies from our laboratory have previously demonstrated that inhibition of mTORC1 increases the ost...