Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p33 | Bone biomechanics and quality | ECTS2016

Assessment of changes in collagen associated with advanced glycation end-products in human bone using vibrational spectroscopy

Schmidt Felix Nikolai , Zimmermann Elizabeth Ann , Puschel Klaus , Amling Michael , Vashishth Deepka , Tang Simon , Busse Bjorn

Introduction: Aging, diabetes and other disease conditions are associated with the accumulation of non-enzymatic collagen cross-links (NE-XL) in human tissues. Non-enzymatic cross-links (i.e. advanced glycation end products (AGEs)), occur at the bone collagen level, where they are associated with individuals increased fracture risk caused by bone’s reduced plasticity.Methods: Here, non-destructive Fourier-transform infrared (FTIR) spectroscopy was u...

ba0001pp50 | Bone biomechanics and quality | ECTS2013

Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis and bisphosphonate treatment in women

Bernhard Andreas , Milovanovic Petar , Hahn Michael , Djonic Danijela , Krause Matthias , Breer Stefan , Pueschel Klaus , Zimmermann Elizabeth A , Djuric Marija , Amling Michael , Busse Bjoern

Bone remodeling is the key process in bone structural reorganization, and its alterations lead to changes in bone mechanical strength. Since osteons reflect different bone remodeling patterns, we hypothesize that the femoral cortex of females with miscellaneous age, disease, and treatment conditions will display distinct osteonal morphology and osteocyte lacunar numbers along with different mechanical properties.The specimens used in this study were coll...