Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Poster Presentations

Bone biomechanics and quality

ba0005p22 | Bone biomechanics and quality | ECTS2016

Finite element analyses predict the mechanical impact of cam-FAI surgery on ovine femurs

Maquer Ghislain , Burki Alexander , Zysset Philippe , Tannast Moritz

Cam femoro-acetabular impingement (FAI) surgery restores hip range of motion by trimming the head–neck junction, which weakens the proximal femur. Sheep femurs resemble cam deformity and might be suitable for evaluating the impact of the surgical correction. Accordingly, this study addressed two questions: How does increasing head-neck resection affect ovine femoral strength? Are quantitative computed tomography (QCT)-based FE models able to discriminate the observed chan...

ba0005p23 | Bone biomechanics and quality | ECTS2016

Impact of visceral adiposity on trabecular bone score in obese postmenopausal women: A cohort study

Moretti Antimo , Gimigliano Francesca , Calafiore Dario , Giamattei Maria Teresa , Iolascon Giovanni

Background: Higher BMI values are associated with greater bone mineral density (BMD) resulting in a site-specific protective effect for fragility fractures. However, pathophysiologic influence of central adiposity on bone quality may oppose the seemingly positive influence of a greater mechanical loading with higher body masses. The objective of our study was to evaluate the impact of visceral fat on trabecular bone microarchitecture in postmenopausal obese women.<p class=...

ba0005p24 | Bone biomechanics and quality | ECTS2016

Epidemiological and biomechanical influences on the prevalence and progression of periprosthetic osteolisis after total hip replacement: analysis with magnetic resonance imaging

Sandoval Manuel Angel , Perez-Coto Ivan , Iglesias Susana , Hernandez-Vaquero Daniel

Introduction and objectives: There is an increasing interest in knowing the factors related to the wear particle-induced disease in total hip replacement (THR), after long-term follow up. Numerous studies have analyzed the development and the destruction patterns of the osteolisis. The objectives of this study were to determine the factors associated with major frequency and severity of this disease and their influence in the osteolytic progression pattern, using magnetic reso...

ba0005p25 | Bone biomechanics and quality | ECTS2016

Effect of paracetamol on bone mechanical properties in rats

Cegiela Urszula , Janas Aleksandra , Folwarczna Joanna , Pytlik Maria , Sliwinski Leszek , Koziel Angelika , Koziol Marzena , Ludwig Rafal

Results of epidemiological studies indicate that paracetamol use may be a risk factor for fracture. The exact mechanism of paracetamol action remains unclear, but it is known to inhibit COX-2. Orchidectomy-induced androgen deficiency was reported to increase COX-2 expression and prostanoid release in rats. The aim of the present study was to investigate the effect of paracetamol on bone mechanical properties in rats with normal androgen levels and with androgen deficiency indu...

ba0005p26 | Bone biomechanics and quality | ECTS2016

Doxazosin prevents the development of estrogen deficiency-induced osteoporosis in rats

Pytlik Maria , Janas Aleksandra , Folwarczna Joanna , Cegiela Urszula , Sliwinski Leszek , Konieczna Agnieszka , Szklanny Ewa , Adamski Lukasz

In postmenopausal women, estrogen deficiency not only interferes with the metabolism of the bone tissue, but also adversely affects the cardiovascular system and can cause hypertension. Doxazosin is often used in the treatment of resistant hypertension, especially in patients with renal failure and hyperlipidemia. Vasodilator effect of doxazosin is associated with selective blocking of α1 receptors in the smooth muscle cells of resistance arterioles. The results of epidem...

ba0005p27 | Bone biomechanics and quality | ECTS2016

Relationships between morphometric, densitometric and mechanical properties of tibiotarsal bone in 14-month-old ostriches (Struthio Camelus)

Charuta Anna , Tatara Marcin , Krupski Witold , Luszczewska-Sierakowska Iwona , Furmanek Miroslaw , Jozwik Artur , Horbanczuk Jaroslaw

The aim of the study was to evaluate relationships between morphometric, densitometric and mechanical properties of tibiotarsus in ostriches (Struthio camelus). 14-month-old males (N=15) and females (N=31) were slaughter to obtain left tibiotarsus. Using computed tomography technique (Somatom Emotion scaner, Siemens), volumetric bone mineral density (vBMD) of the trabecular (Td) and cortical bone (Cd), mean voulmetric bone mineral density (MvBMD) and...

ba0005p28 | Bone biomechanics and quality | ECTS2016

Alendronate therapy improves anterior vertebral microstructure in osteoporotic bone facilitating fracture risk reduction

vom Scheidt Annika , Krause Matthias , Puschel Klaus , Amling Michael , Busse Bjorn

Although the fracture risk reduction under bisphosphonate treatment in osteoporosis is clinically well established, it remains understudied why the efficacy of bisphosphonate therapy is higher for the prevention of vertebral fractures compared to other fractures.Our aim was to investigate whether anti-resorptive therapy with alendronate would result in different regional variations of structural indices in the vertebral body. We investigated the microstr...

ba0005p29 | Bone biomechanics and quality | ECTS2016

Modified stable supracondylar corrective osteotomy technique for Genu Valgum

Rastogi Surbhit , Dawar Hitesh , Wani Sayim , Raina Deepak

Introduction: Genu valgum is a common deformity in Indian (aediatric population owing to nutritional and social reasons), and is often neglected. The patient, especially females, present at around marriageable age demanding a single stage, cosmetic, implantless correction of deformity.Objectives: To present a technique of modified supracondylar osteotomy for correction of genu valgum deformity and evaluation of results.Materials an...

ba0005p30 | Bone biomechanics and quality | ECTS2016

Chemical composition of the trabecular bone with and without osteoarthritis

Baek Myong-Hyun , Kim Kwang-Kyun

Purpose: The aim of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the human distal femur at the microstructural level.Methods: The subchondral trabeculae were obtained from the middle of medial articular surface of the distal femurs in the two cadavers (one is with and the other is without OA). Raman spectroscopy, a non-destructive technique, was employed to determine the chemical information of the trabe...

ba0005p31 | Bone biomechanics and quality | ECTS2016

Site specific bone loss induced by spaceflight in mice: a multiscale evaluation of trabecular and cortical structure and quality

Gerbaix Maude , Gnyubkin Vasily , Delphine Farlay , Helene Follet , Patrick Ammann , Cecile Olivier , Francoise Peyrin , Norbert Laroche , Boris Shenkman , Guillemette Gauquelin-Koch , Laurence Vico

Intrinsic quality, micro and nano structure of bone after 1 month of spaceflight and during 1 week of recovery had never been investigated. The aim was to explore these properties in appendicular and axial skeleton of mature mice.Ten C57/Bl6 male mice flew on the 30-day space Russian BION-M1 high-orbit satellite mission (Biomedical Ethics Commission of IBMP, n°319). Five were euthanized 12 h after landing, the others 8 days later. A ground control g...

ba0005p32 | Bone biomechanics and quality | ECTS2016

Characterization of bone using ultrasonic waves and structural borne acoustic waves

Aygun Haydar , Barlow Chris , Yule Lawrence

An orthogonally-anisotropic Biot-Johnson-Allard (BJA) model in which the dependences of tortuosity on porosity and angle are determined empirically from acoustic measurements on bone replicas has been developed. Phase velocities and attenuations of the fast and slow waves versus frequency, porosity and angle of propagation have been predicted by using BJA model. The attenuation of the fast wave is below 0.5 Np/m throughout the frequency and propagation angle range. The attenua...

ba0005p33 | Bone biomechanics and quality | ECTS2016

Assessment of changes in collagen associated with advanced glycation end-products in human bone using vibrational spectroscopy

Schmidt Felix Nikolai , Zimmermann Elizabeth Ann , Puschel Klaus , Amling Michael , Vashishth Deepka , Tang Simon , Busse Bjorn

Introduction: Aging, diabetes and other disease conditions are associated with the accumulation of non-enzymatic collagen cross-links (NE-XL) in human tissues. Non-enzymatic cross-links (i.e. advanced glycation end products (AGEs)), occur at the bone collagen level, where they are associated with individuals increased fracture risk caused by bone’s reduced plasticity.Methods: Here, non-destructive Fourier-transform infrared (FTIR) spectroscopy was u...

ba0005p34 | Bone biomechanics and quality | ECTS2016

Abstract withdrawn....

ba0005p35 | Bone biomechanics and quality | ECTS2016

Bone material properties as measured by Reference Point Indentation are low in subjects with acromegaly

Malgo Frank , Hamdy Neveen A T , Pereira Alberto M , Biermasz Nienke R , Appelman-Dijkstra Natasha M

Introduction: Acromegaly is a rare disease caused by excess growth hormone (GH) production by an adenoma of the anterior pituitary gland. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of a relatively normal Bone Mineral Density (BMD). There are no data on bone material properties in patients ...

ba0005p36 | Bone biomechanics and quality | ECTS2016

Finite element analysis of osteoporotic lumbar vertebrae L1 under dynamic loading

Ardatov Oleg , Alekna Vidmantas , Maknickas Algirdas , Tamulaitiene Marija , Kacianauskas Rimantas

The present study introduces in silico analysis of osteoporotic lumbar vertebrae L1 due to dynamic compressive load.Objective: To define the reduction of load carrying capacity caused by various grades of osteoporosis.Materials and methods: The three-dimensional inhomogeneous continuum problem was formulated for simulation purposes. The L1 vertebra model consists of cortical shell, trabecular network and poste...

ba0005p37 | Bone biomechanics and quality | ECTS2016

Elemental composition of compact human bone correlated with the osteocyte network

Roschger Andreas , Roschger Paul , Repp Felix , Wagermaier Wolfgang , Weinkamer Richard , Klaushofer Klaus , Fratzl Peter

Spatial distributions of major and minor chemical elements are supposed to change during tissue maturation and due to bone diseases. Previous studies suggested that osteocytes have the ability to interact with the bone matrix of their environment. For this interaction osteocytes make use of the big inner surface of the osteocyte lacuno-canalicular network (OLCN) in which they are accommodated. The aim of this study was to quantify spatial correlations between the elemental com...

ba0005p38 | Bone biomechanics and quality | ECTS2016

Arthritis induces early bone structural degradation and mechanical weakness

Vidal Bruno , Cascao Rita , Finnila Mikko , Lopes Ines , Saarakkala Simo , Canhao Helena , Fonseca Joao

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...

ba0005p39 | Bone biomechanics and quality | ECTS2016

Depth and location dependence of subchondral trabecular structure across the tibia in human osteoarthritic knee versus normal knee: a micro-CT study

Bouhadoun Hamid , Engelke Klaus , Laredo Jean Denis , Chappard Christine

Objective: To determine differences between osteoarthritic (OA) knees with normal knees for subchondral trabecular bone structure according to depth and location in the tibial plateau.Methods: In a population of 30 cadaveric left knees (18 women and 12 men, mean age: 79.1 years±8.2, range: 63–90) the Kellgren-Lawrence (KL) score was determined from post mortem radiographs: OA=KL&gE;2 (n=6 women, n=5 men) and controls=KL &#8804...

ba0005p40 | Bone biomechanics and quality | ECTS2016

Atypical fractures of femur after longterm bisphosphonates treatment: two years follow up

Vyskocil Vaclav , Pavelka Tomas

The authors present own group of 4213 patients treated with bisphosphonates (BFs) and development of atypical fractures (AF) after 2 years follow up. At the beginning 2147 patients were treated with alendronate and 2066 with ibandronate. Totally 15 fractures were found in the alendronate group (two in adult patients with osteogenesis imperfecta) and 14 in the ibandronate group (one in adult patients with osteogenesis imperfecta). All radiographic examinations were subjected to...

ba0005p41 | Bone biomechanics and quality | ECTS2016

Investigation of the potential link between mechanosensory proteins PC1/PC2 and craniosynostosis

Katsianou Maria , Piperi Christina , Korkolopoulou Penelope , Themistocleous Marios S , Basdra Efthimia K , Papavassiliou Athanasios G

Background: Skull development is a tightly regulated process that occurs along the osteogenic interfaces of the cranial sutures that allow rapid bone formation at the edges of the bone fronts. Premature closure of cranial sutures can result in pathological conditions such as Craniosynostosis. The mechanosensory proteins Polycystin 1 (PC1) and 2 (PC2) have been shown to regulate skeletal development and potentially suture formation.Aim: The aim of study w...

ba0005p42 | Bone biomechanics and quality | ECTS2016

Sexually dimorphic response on bone development after neonatal thymectomy in rats

de Mello Wagner Garcez , Kiill Noelle Egidia Watanabe , Kayahara Gisele Mitsui , Nascimento Olivia Borghi , Marqui Narayana Guimaraes , Crivelini Marcelo Macedo , Louzada Mario Jefferson Quirino , Antunes-Rodrigues Jose , de Castro Joao Cesar Bedran

The effects of neonatal thymectomy, at 3 days of age, on skeletal sexual dimorphism and bone quality during the development were examined in male and female Wistar rats. Rats were euthanized at 20, 40, or 120 postnatal days and femurs were collected. The Biomechanical compression test was used to evaluate bone breaking strength, energy-to-fracture, and extrinsic stiffness. During the prepubertal period, the neonatal thymectomy increases extrinsic stiffness of bone tissue signi...