Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p22 | Bone biomechanics and quality | ECTS2016

Finite element analyses predict the mechanical impact of cam-FAI surgery on ovine femurs

Maquer Ghislain , Burki Alexander , Zysset Philippe , Tannast Moritz

Cam femoro-acetabular impingement (FAI) surgery restores hip range of motion by trimming the head┬ľneck junction, which weakens the proximal femur. Sheep femurs resemble cam deformity and might be suitable for evaluating the impact of the surgical correction. Accordingly, this study addressed two questions: How does increasing head-neck resection affect ovine femoral strength? Are quantitative computed tomography (QCT)-based FE models able to discriminate the observed chan...

ba0001pp451 | Osteoporosis: treatment | ECTS2013

Estimation of vertebral and femoral strength during the first three years of denosumab therapy using an alternative smooth non-linear finite element methodology

Zysset Philippe , Pahr Dieter , Engelke Klaus , Genant Harry , McClung Michael , Kendler David , Recknor Christopher , Kinzl Michael , Schwiedrzik Jakob , Museyko Oleg , Wang Andrea , Libanati Cesar

Denosumab subcutaneous administration every 6 months reduced the incidence of new fractures in postmenopausal women with osteoporosis by 68% at the spine and 40% at the hip over 36 months compared with placebo in the FREEDOM study (Cummings et al., NEJM, 2009:361:756). This efficacy was supported by differential improvements from baseline in vertebral and femoral strength at 36 months (18.2 and 8.6%, respectively) estimated by an established voxel-based finit...