Searchable abstracts of presentations at key conferences on calcified tissues

ba0005s5.2 | Molecular Clocks | ECTS2016

Good times, bad times: (patho)physiology of diurnal rhythms

van der Horst Gijsbertus (Bert)

Like most organisms, we have developed an internal time keeping system that drives daily rhythms in metabolism, physiology and behavior, and allows us to optimally anticipate to the momentum of the day. At the basis of circadian timekeeping lies an intracellular molecular oscillator in which a set of clock genes cyclically regulate their own expression with an approximate (circa) 24-hour (dies) periodicity. The mammalian circadian system consists of a light-entrainable master ...

ba0005p61 | Bone development/growth and fracture repair | ECTS2016

Advanced phase gestational jet lag reduces bone mass of adult offspring

van der Eerden Bram , Chaves Ines , Azimzadeh Pedram , Schreuders-Koedam Marijke , Reiss Irwin , van Leeuwen Johannes , van der Horst Gijsbertus

The mammalian circadian clock is tightly controlled by clock genes, which have been shown to regulate up to 20% of the transcriptome in any given tissue. Evidence is accumulating that light-modulation perpetually affects circadian clock performance. In accordance, shift work or chronic jet lag is associated with higher risk of disease later in life, including osteoporosis. In this study, we assessed whether gestational jet lag in mice reduces bone mass postnatally.<p class...