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Bone Abstracts (2013) 1 PP100 | DOI: 10.1530/boneabs.1.PP100

ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)

A mixture of GOS/FOS ® added to a low calcium (ca) diet improved ca, phosphorus (p) and magnesium (mg) absorption: experimental model in normal growing rats

Gabriel Bryk 1, , Macarena Gonzales Chaves 1, , Clarisa Marotte 1, , Daniela Medina 2 , Magali Zeni Coronel 2 , Maria Luz de Portela 3 & Susana Noemi Zeni 1

1Cátedra De Bioquímica General y Bucal. Fac. De Odontología, Uba, Buenos Aires, Argentina; 2Laboratorio de Enfermedades Metabólicas Óseas, Hospital de Clínicas, Instituto de Inmunología, Genética y Metabolismo (Inigem) Conicet- Uba, Buenos Aires, Argentina; 3Cátedra de Nutrición. Facultad de Farmacia y Bioquímica Uba, Buenos Aires, Argentina.

A mixture of Galacto-oligosaccharides (GOS) and Fructooligosaccharides (FOS) are added to commercial infant formula to promote an intestinal microbiota similar to that prevalent in breast-fed infants to improve Ca bioavailability and general health, but their mechanisms are under debate.

Our objective was to evaluate the beneficial effects of the mixture of GOS/FOS added to infant formulae, on the absorption of Ca, Mg and P of a low Ca diet. Changes in intestinal pH, absorption percentage (Abs) and in bone mineral density (BMD) were determined in an experimental model of normal growing rats.

Male Wistar rats (n=10/group) were fed one of the three experimental diets from weaning to 40 days of age. All diets were prepared according to AIN’93-G rodent diet except for Ca content. A.5 and A.3 contained 0.5 and 0.3% of Ca, respectively; GF.3 contained 0.3%Ca and 5.3% of GOS/FOS.

Dietary consumption and body weight (BW) were evaluated three times per week and weekly, respectively. Ca, Mg and P absorption percentage was determined at the beginning and during the last 3 days of the study. At the end of the experience (t=f), caecal pH, total skeleton (tsk) and tibia BMDs were evaluated by DXA (Lunar corp.)

Results: at=f (mean±SD)

Table 1
Caecal PhTibia BMDtsk BMD (mg/cm2)%Ca Abs% Mg Abs.% P Abs.
No differences in pH, absorptions and BMD were observed at the beginning of the study. BW increases were not significantly different among groups. At t=f, GF.3 presented the lowest caecal pH and showed a significant increment of all studied parameters compared to A.3 (** P<0.05). G.3 also had higher tskBMD, and Ca, Mg, P Abs. than A.5 diet (* P<0.05).

Conclusion: These results evidence the increment in Ca, Mg and P absorption percentage and suggest the benefic effect of GOS/FOS in bone health during normal growth. N.V.Nutricia. Grant of CONICET: PIP 002/2011.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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