Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

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European Calcified Tissue Society Annual Congress, 17 - 20 May 2014; Prague, Czech Republic

Oral Communications

Important pathways in bone biology and cancer

ba0003oc5.1 | Important pathways in bone biology and cancer | ECTS2014

In vivo efficacy of a pharmacological inhibitor of TNAP to prevent arterial calcification and its associated cardiac hypertrophy and mortality

Sheen Campbell , Chhea Thangchanthida , Pinkerton Antony , Jackson Michael , Millan Jose Luis

Medial vascular calcification (MVC) is a pathological condition common to a variety of diseases, including chronic kidney disease, diabetes, obesity, generalized arterial calcification of infancy, arterial calcification due to deficiency of CD73, and Keutel syndrome. These diseases share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. We developed a mouse model that overexpresses human TNAP in vascular smooth muscle cells, ...

ba0003oc5.2 | Important pathways in bone biology and cancer | ECTS2014

Regulation of bone metastasis by the IKKβ/FoxO3a axis

Marino Silvia , Logan John G. , Sophocleous Antonia , Mollat Patrick , Mognetti Barbara , Ventura Luca , Sims Andrew H. , Rucci Nadia , Ralston Stuart H. , Idris Aymen I.

IκB Kinase β (IKKβ), a key component of NFκB signaling, plays an important role in bone disease and cancer. Genetic and pharmacological inhibition of IKKβ/NFκB signaling increase bone mass and protect against ovariectomy- and inflammation-induced bone loss. Here, we describe a previously unknown role of the IKKβ/FoxO3a axis in bone metastasis associated with breast cancer. We observed that IKKβ expression is prevalent in invasive breast ...

ba0003oc5.3 | Important pathways in bone biology and cancer | ECTS2014

Beta haemoglobin (hbb) is a novel marker of breast cancer progression

Capulli Mattia , Angelucci Adriano , Teti Anna , Sanita Patrizia , Ventura Luca , Rucci Nadia

Breast cancer (BrCa) patients with metastases restricted to bone (BO) show a longer overall survival compared to BrCa patients developing bone and visceral metastases (BV). To unveil the molecular mechanisms that segregate these two BrCa patient groups, we performed microarray analyses on bone metastasis samples from BO and BV patients, finding in the latter a set of up-regulated genes involved in oxygen metabolism. We focused on Hemoglobin B (HBB) and evaluated its expression...

ba0003oc5.4 | Important pathways in bone biology and cancer | ECTS2014

WNT5A has anti-prostate cancer effects and protects against bone metastases

Thiele Stefanie , Gobel Andy , Hippauf Sandra , Rachner Tilman D. , Muders Michael , Fussel Susanne , Bernhardt Ricardo , Jakob Franz , Rauner Martina , Hofbauer Lorenz C.

Prostate cancer (PCa) is the most common cancer type in older men and often metastasizes to bone in advanced stages. Wnt proteins are implicated in carcinogenesis and especially WNT5A has been discussed to influence the clinical outcome of various cancer types, including PCa. In addition, WNT5A stimulates osteogenic differentiation and may thus not only be involved in PCa development, but also in the formation of subsequent skeletal metastasis. Here, we determined the role of ...

ba0003oc5.5 | Important pathways in bone biology and cancer | ECTS2014

Rs55710688 in the Kozak sequence of WNT16 increases translation efficiency and is associated with osteoporosis related parameters

Hendrickx Gretl , Boudin Eveline , Fijalkowski Igor , Nielsen Torben Leo , Andersen Marianne , Brixen Kim , Van Hul Wim

Recent studies confirmed the role of WNT16 in bone mineral density (BMD), bone strength and fracture risk. These findings made WNT16 interesting for further genetic and functional studies to clarify its effect on osteoporosis related parameters.A WNT16 candidate gene association study was performed in men from the Odense Androgen Study (OAS). Five tagSNPs and one multimarker test were selected for genotyping to cover most of th...

ba0003oc5.6 | Important pathways in bone biology and cancer | ECTS2014

Enhanced load adaptation in long bone of cathepsin K-deficient mice

Bonnet Nicolas , Duong Lee , Ferrari Serge

Gene deletion or treatments with a cathepsin K (CatK) inhibitor in mature preclinical models result not only result in lower bone resorption but also in higher bone formation (BF) on both remodeling and modeling surfaces. Although increased production of clastokines and matrix-derived growth factors may explain the increased BF at remodeling surfaces, the mechanisms for greater BF at modeling surfaces, including the periosteum, remain unexplained. We hypothesized that the abse...