Searchable abstracts of presentations at key conferences on calcified tissues
Previous issue | Volume 3 | ECTS2014 | Next issue

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

Card image cap
European Calcified Tissue Society Annual Congress, 17 - 20 May 2014; Prague, Czech Republic

Poster Presentations

Paediatric bone disease

ba0003pp406 | Paediatric bone disease | ECTS2014

Early intervention with anti-resorptives is essential in OI: a longterm murine study

Raggio Cathleen , Marino Josephine , Doty Steve , Pleshko Nancy , Boskey Adele

The oim/oim mouse resembles type III OI. Our study mimics clinical questions: is RANK-Fc as efficacious as ALN in reducing fracture number? Is RANK-Fc safe to administer to children? Is there any advantage to receiving RANK-Fc treatment post adolescence, following no treatment or ALN treatment from infancy through adolescence?All animal work was done under an IACUC-approval. Mice – n=200, WT or oim/oim. Treatment spanned a...

ba0003pp407 | Paediatric bone disease | ECTS2014

Glucocorticoid-treated boys with Duchenne muscular dystrophy DMD and osteoporosis have higher bone matrix mineralization before and after i.v. bisphosphonate therapy

Roschger Paul , Misof Barbara M. , Klaushofer Klaus , Rauch Frank , Ward Leanne M

Duchenne muscular dystrophy (DMD) causes progressive muscle weakness and loss of ambulation. While glucocorticoid (GC) therapy improves motor function, many boys sustain fractures due to osteoporosis. Recently, i.v. bisphosphonate (i.v.BP) therapy has shown promise in the treatment of DMD-related osteoporosis. At the same time, bone histomorphometry revealed lowered bone volume and significant reductions in bone formation pre-i.v.BP treatment, and a further drop after 2 years&...

ba0003pp408 | Paediatric bone disease | ECTS2014

Effect of GOS/FOS on calcium and phosphorus absorption and retention during recovering from undernutrition: experimental model in normal growing rats

Bryk Gabriel , Coronel Magali Zeni , Medina Daniela , Mandalunis Patricia , de Portela Maria Luz Pita Martin , Susana Zeni

During early life undernutrition impairs normal weight and height gain that affects bone health. During recovering it is required an extra-amount of Ca to ensure the high demands of bone mineralization. A mixture of galactooligosaccharides (GOS) and fructooligosaccharides (FOS) would be a useful tool to increase mineral intestinal absorption to enhancing the amount of Ca to be retained into bone. Our objective was to evaluate, in an experimental model of protein restriction (P...

ba0003pp409 | Paediatric bone disease | ECTS2014

Ibandronate in the treatment of pediatric osteoporosis

Kutilek Stepan , Plasilova Ivana

Background: Orally administered ibandronate is an effective agent in the treatment of postmenopausal osteoporosis. There are only scarce data regarding its use in children with impaired bone health.Objectives: To evaluate the effect of oral ibandronate on bone health in osteoporotic children and adolescents.Patients, materials and methods: We enrolled six patients (all boys; mean age 15.7±3.8 years; range 8–18 years) with...

ba0003pp410 | Paediatric bone disease | ECTS2014

Bone health in children with hemolytic anemia: does the pathogenesis of hemolysis determine the phenotype of bone alteration?

Schundeln Michael , Goretzki Sarah , Hauffa Pia , Marschke Laura , Wieland Regina , Bauer Jens , Hauffa Berthold , Grasemann Corinna

Introduction: Bone health in patients with sickle cell disease and thalassemia is impaired. These patients feature altered parameters of bone metabolism and bone mineral density.Aim and design: To investigate bone health in patients with hemolytic anemia we conducted a cross-sectional analysis in our Hematology Outpatient Clinic at the Children’s Hospital Essen. The largest subgroups within our cohort are patients with homozygous sickle cell (HBSS) ...

ba0003pp411 | Paediatric bone disease | ECTS2014

Tricho-rhino-phalangeal syndrome TRPS: the new three cases from Poland

Matusik Pawel , Forys-Dworniczak Elzbieta , Kalina-Faska Barbara , Januszek-Trzciakowska Aleksandra , Malecka-Tendera Ewa

Tricho-rhino-pharyngeal syndrome (TRPS) is a rare genetic disorder, which is characterized by craniofacial and skeletal abnormalities. This report presents three cases of TRPS (two sporadic and one familial). Clinical presentation included typical facial features (pear-shape nose, long flat philtrum, thin upper vermilion border and protruding ears), thin, sparse scalp hair and different skeletal abnormalities with normal mentation. Case 1: 5.5-year-old boy with short stature (...

ba0003pp412 | Paediatric bone disease | ECTS2014

Team management of young persons with osteogenesis imperfecta

Hagberg Maud , Lowing Kristina , Malmgren Barbro , Kumlien Catharina , Eva AEstrom

The pediatric osteogenesis imperfecta (OI) team at our university hospital was established in 1991. The multi- and inter-disciplinary team consists of: pediatric neurologist, nurse, nursing assistant, physiotherapist, occupational therapist, orthopedic surgeon, orthotist, radiologist, dentist and geneticist. We also have a close collaboration with other specialists.Our assignment is high qualified diagnostics, functional assessments and also individualiz...