Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

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European Calcified Tissue Society Annual Congress, 17 - 20 May 2014; Prague, Czech Republic

Poster Presentations

Steroid hormones and receptors

ba0003pp413 | Steroid hormones and receptors | ECTS2014

Chondroitin sulfate chains are co-receptors for interleukin- 34

Heymann Dominique , Segaliny Aude , Brion Regis , Maillasson Mike , Mortier Erwan , Jacques Yannick , Goff Benoit Le

Interleukin- 34 (IL34) is a new, challenging cytokine discovered in 2008. It promotes the proliferation, survival and differentiation of the monocyte/macrophage lineage with almost the same efficiency as the macrophage-colony stimulating factor (M-CSF). IL34 has already been described to play a key role in various musculoskeletal bone diseases such as bone giant cell tumors or in rheumatoid arthritis. These ‘twin’ cytokines share a lot of functional similarities whic...

ba0003pp414 | Steroid hormones and receptors | ECTS2014

Glucocorticoids suppress inflammation in arthritis via the glucocorticoid receptor in non-hematopoietic cells

Baschant Ulrike , Culemann Stephan , Koenen Mascha , Zhou Hong , Seibel Markus , Hofbauer Lorenz , Tuckermann Jan

Owing to their anti-inflammatory effects, steroid therapy using glucocorticoids (GCs) is still part of the treatment of rheumatoid arthritis (RA), despite several severe side effects like glucocorticoid-induced osteoporosis (GIO). Until now the molecular mechanisms underlying the beneficial and side effects of GC therapy are poorly understood. GCs exert their actions via the glucocorticoid receptor (GR) that alters gene expression by either binding as a dimer to GC response el...

ba0003pp415 | Steroid hormones and receptors | ECTS2014

Vitamin D deficiency and prevention; what is the position of European Calcified Tissue Society?

Adami Silvano , Bischoff-Ferrari Heike , Bouillon Roger , Cashman Kevin , Fuleihan Ghada El-Hajj , Lamberg-Allardt Christel , Obermayer-Pietsch Barbara , Lips Paul

Vitamin D deficiency is common within Europe and the Middle East, especially in risk groups. While treatment is simple, there is no consensus on the diagnostic threshold for deficiency and the required dose. The Institute of Medicine and the Endocrine Society have established guidelines on the required 25-hydroxyvitamin D (25(OH)D) levels, supplementation doses and (extra)skeletal effects of vitamin D, coming to very different conclusions. The European Calcified Tissue Society...

ba0003pp416 | Steroid hormones and receptors | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead to multiple side effects including glucocorticoid induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by the glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation of genes is causing side effects.Using conditional and function selective mutant mic...