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Bone Abstracts (2014) 3 PP275 | DOI: 10.1530/boneabs.3.PP275

Osteoporosis: pathophysiology and epidemiology

Influence of vitamin D deficiency to structural and functional state of bone tissue in schoolchildren

Vladyslav Povoroznyuk1, Olena Tyazhka2, Nataliya Balatska1, Tetyana Budnik3, Inga Kubey4 & Nataliia Haliyash4

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1D.F. Chebotarev Institute of gerontology NAMS Ukraine, Kyiv, Ukraine; 2Bogomolets National Medical University, Kyiv, Ukraine; 3Lugansk State Medical University, Lugansk, Ukraine; 4I.Y. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine.


The aim of the work was to determine the influence of vitamin D deficiency on bone mineral density in schoolchildren.

Methods: There were examined 304 children aged 10–18 years. The boys consisted 55.0%. The average age of boys was 12.9±0.2 and girls – 12.4±0.2 years old. Researches included ultrasound densitometry of calcaneus by SAHARA (Hologic), blood chemistry, 25(OH)D and intact parathyroid hormone (iPTH) in plasma were determined by Elecsys 2010. Also, it was evaluated the average content of calcium and vitamin D in the diet form the products consumption frequency questionnaire.

Results: Vitamin D deficiency was founded in 92.2% of schoolchildren, and vitamin D insufficiency was diagnosed in 6.1% of cases. Secondary hyperparathyroidism was verified in 0.9% of children. The average level of consumption of calcium and vitamin D in children was below recommended data, and consisted (Me 649 (488.7; 691.86)) mg/day for calcium and (Me 68.69 (58.45; 117.3)) IU/day for vitamin D.

Children with vitamin D insufficiency had significantly higher data of structural and functional state of bone tissue in comparison with the data of pupils with severe deficiency of vitamin D: stiffness index 105.03±6.12 vs 93.7±2.51% (P<0.02); BMD 0.574±0.024 vs 0.528±0.019 (P<0.02) and speed of sound 1573.61±6.70 vs 1557.2±5.41 (P<0.01).

Conclusion: High level of vitamin D deficiency (92.2%), secondary hyperparathyroidism (0.9%), low data of ultrasound densitometry in severe vitamin D deficient children make doctors to research the effective methods of treatment and prophylactics of revealed disorders.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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