Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2014) 3 PP40 | DOI: 10.1530/boneabs.3.PP40

ECTS2014 Poster Presentations Bone development/growth and fracture repair (55 abstracts)

NFI-C regulates osteoblast differentiation via control of osterix expression

Joo-Cheol Park & Dong-Seol Lee

School of Dentistry, Seoul National University, Seoul, Republic of Korea.

In bone marrow, bone marrow stromal cells (BMSCs) have the capacity to differentiate into osteoblasts and adipocytes. Onset of osteoporosis with age stems in part from the enhanced bone marrow adipogenesis that represses osteogenesis. In this study, we demonstrate that disruption of nuclear factor I-C (NFI-C) impairs osteoblast differentiation and bone formation, and increases bone marrow adipocytes. Interestingly, NFI-C controls postnatal bone formation but does not influence prenatal bone development. Moreover, Nfic-deficiency remarkably increases bone marrow fat in mice similar to osteoporotic patients. We also found decreased NFI-C expression in osteogenic cells from human osteoporotic patients. Notably, transplantation of Nfic-overexpressing BMSCs stimulates osteoblast differentiation and new bone formation, but inhibits adipocyte differentiation by suppressing PPARγ expression in Nfic−/− mice showing an age-related osteoporosis-like phenotype. Finally, NFI-C directly regulates Osterix expression but acts downstream of the BMP 2–Runx2 pathway. These results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. Therefore, regulation of NFI-C expression in BMSCs could be a novel therapeutic approach for treating age-related osteoporosis.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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