ICCBH2015 Poster Presentations (1) (201 abstracts)
Effect of baseline vitamin D status on serum 25(OH) D level and body composition in breastfed infants on vitamin D supplementation
Justyna Czech-Kowalska 1 , Maciej Jaworski 2 , Dorota Maksym 1 , Monika Nowakowska-Rysz 1 , Grazyna Wygledowska 3 , Beata Pawlus 4 , Anna Zochowska 5 , Maria Kornacka 6 & Anna Dobrzanska 1
1Department of Neonatology and Neonatal Intensive Care, The Children’s Memorial Health Institute, Warsaw, Poland; 2Department of Biochemistry Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland; 3Department of Neonatology, Miedzyleski Specialist Hospital, Warsaw, Poland; 4Department of Neonatology, Holy Family Hospital, Warsaw, Poland; 5Department of Neonatology, Public Hospital, Otwock, Poland; 6Department of Neonatology, Warsaw Medical University Hospital, Warsaw, Poland.
Objectives: Vitamin D intake at a dose 400 IU/d is recommended for breastfed infants and is considered as sufficient. Vitamin D status is connected with bone mass and fat mass. We aimed to assess, if 400 IU/d has the same efficiency and impact on body composition in infants with different vitamin D status at birth (<20 ng/ml vs ≧20 ng/ml).
Methods: 148 breastfed infants were supplemented with 400 IU/d of cholecalciferol up to 6 months of age. Serum 25(OH)D, iPTH and dual-x-ray absorptiometry (Lunar, Prodigy) were performed after birth and 3, and 6 months later. Participants were divided according to cord blood 25(OH) D level (group 1: 25(OH) D <20 ng/ml, group 2: 25(OH) D ≧20 ng/ml) (Table 1).
Results: A total of 124 (83.8%) infants completed the study. 25(OH) D level and compliance were similar in the study groups at 3 and 6 months. The prevalence of 25(OH) D level ≧20 ng/ml (94% vs 100%) and >30 ng/ml (64% vs 59%) were similar in both study groups after 6 months of vitamin D supplementation, respectively. The higher increment in 25(OH) D level was associated with the higher percentage change in bone mass, fat mass and length in vitamin D deficient infants between baseline and 6 months of age (Table 1).
| Parameters | Group 1 (n=78) Cord blood 25 (OH) D <20 ng/ml | Group 2 (n=46) Cord blood 25 (OH) D ≧20 ng/ml | P value |
| 25 (OH) D (ng/ml) | |||
| Cord blood | 11.5±4.2 | 27.6±5 | 0.0001 |
| 3 months | 33.8±7.8 | 34.7±7.7 | >0.05 |
| 6 months | 32.2±7 | 34.6±9.2 | >0.05 |
| Increment in 25(OH)D (ng/ml) | 20.7±8.7 | 6.7±9.5 | 0.0001 |
| 25(OH)D % change (%) | 227±146 | 27±36 | 0.0001 |
| PTH % change (%) | 410±345 | 408±301 | >0.05 |
| BMD % change (%) | 50.3±9 | 43±14 | 0.03 |
| FM % change (%) | 279±122 | 221±85 | 0.01 |
| LBM % change (%) | 74.7±22 | 74.7±19 | >0.05 |
| Weight % change (%) | 107±32 | 97±26 | >0.05 |
| Length % change (%) | 33±11 | 29±9 | 0.002 |
Conclusions: Vitamin D supplementation at a dose 400 IU/d allowed to achieve 25(OH) D level>20 ng/ml even in infants with vitamin D deficiency at birth. Threefold higher increment in 25(OH) D level was associated with higher percentage change of bone and fat mass but not lean body mass in vitamin D deficient infants.
Financial support: Research grant of Nutricia Foundation No. RG 3/2010
Disclosure: The authors declared no competing interests.
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