Searchable abstracts of presentations at key conferences on calcified tissues
Previous issue | Volume 5 | ECTS2016 | Next issue

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

Card image cap

Poster Presentations

Calciotropic and phosphotropic hormones and mineral metabolism

ba0005p86 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Possible paracrine effects of fibroblast growth factor-23 in the regulation of intestinal calcium absorption

Wongdee Kannikar , Teerapornpuntakit Jarinthorn , Charoenphandhu Narattaphol

As a bone-derived hormone that regulates phosphate homeostasis and renal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production, fibroblast growth factor (FGF)-23 has been postulated to indirectly control calcium and bone metabolism by modulating the levels of phosphate and 1,25(OH)2D3. However, the presence of FGF receptor-1 (FGFR-1) proteins in the intestinal epithelial cells suggests that the intestine may directly respond t...

ba0005p87 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Reciprocal correlation between iron and calcium transport and the hepcidin-enhanced calcium absorption in the duodenum of hemizygous beta-globin knockout thalassemic mice

Charoenphandhu Narattaphol , Kraidith Kamonshanok , Teerapornpuntakit Jarinthorn , Savasti Saovaros

A decrease or absence of beta-globin production in erythroid cells causes a hereditary anemic disorder known as beta-thalassemia, which is associated with ineffective erythropoiesis, iron overload, growth retardation, osteopenia, and osteoporosis. Our recent investigation revealed that beta-thalassemia led to osteoclast-mediated bone resorption and the impaired intestinal calcium absorption, the latter of which modestly responded to conventional 1,25-dihydroxyvitamin D3</...

ba0005p88 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Trabecular (Spine) bone density increases significantly in the first 6 months after weaning (Factors Affecting Bone Formation After Breastfeeding Pilot Study (FABB-Pilot))

Cooke-Hubley Sandra , Mugford Gerry , Valcour James , Wahl Michael , Woodrow Janine , Adachi J D , Kovacs Christopher S

Breastfeeding women resorb trabecular bone to supply much of the calcium content of milk. Few studies have examined the speed and extent of BMD recovery after weaning, or the factors that predict a greater post-lactation increase in BMD. We hypothesize that weight-bearing, nutrition, hormones, and other factors facilitate bone formation after lactation.The aims of the Factors Affecting Bone Formation After Breastfeeding Pilot Study (FABB-Pilot) were to d...

ba0005p89 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Endogenous expression and biological functionality of secreted Klotho in human mesenchymal stem cells

Mentrup Birgit , Pauslus Sofia , Krug Melanie , Hafen Bettina , Jakob Franz

The biological relevance of Klotho in aging processes was impressively demonstrated in transgene and knock out mouse experiments and its impact on calcium, vitamin D and phosphate metabolism suggests multifunctional modes of action.The human alpha Klotho gene encodes two transcripts, one for a protein of 130 kDa with a short intracellular and a transmembrane region and the two extracellular domains KL1 and KL2. A second transcript exists due to alternati...

ba0005p90 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance

Andrukhova Olena , Zhang Jinwei , Alessi Dario , Erben Reinhold

Pseudohypoaldosteronism type II (PHAII) is a hereditary disease characterized by hypertension, hypercalciuria and osteopenia. PHAII is caused by mutations in with-no-lysine kinase 1 (WNK1), WNK4, or the cullin RING ligase family members kelch-like 3 (KLHL3) or cullin 3 (CUL3). All mutations result in up-regulation of the WNK signalling pathway which activates thiazide-sensitive Na-Cl cotransporters (NCC) in renal distal tubules, leading to salt retention and hypertension in PH...

ba0005p91 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

PTH and vitamin D in Inuit and non-Inuit in Greenland

Andersen Stig , Schaebel Louise K. , Heickendorf Lene , Mosekilde Leif , Laurberg Peter

Background: Sun exposure may be limited in Arctic populations and Greenland Inuit have adapted to the Arctic environment. The influence of chronic low vitamin D level on PTH to uphold a normal serum calcium remains to be elucidated.Objective: To describe the association between PTH and factors known to influence PTH-, including vitamin D (25OHD) and calcium, in Arctic populations.Methods: Inuit and non-Inuit in the capital city Nuu...

ba0005p92 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

The analysis of missed diagnosis and misdiagnosis of 144 tumor-induced osteomalacia patients

Feng Juan , Jiang Yan , Wang Ou , Li Mei , Xing Xiao-ping , Meng Xun-wu , Xia Weibo

Introduction: Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome which is usually induced by mesenchymal tissue tumor with excessive secretion of FGF23. The misdiagnosis of TIO is frequently seen in clinic. Therefore, this study is aimed to describe the misdiagnosed situation of TIO, explore the possible underlying reasons for missed diagnosis and misdiagnosis through the analysis of 144 TIO patients, and improve clinicians’ awareness of TIO.<...

ba0005p93 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats

Erjavec Igor , Bordukalo-Niksic Tatjana , Grgurevic Lovorka , Cicin-Sain Lipa , Vukicevic Slobodan

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies, TPH1 deletion either had no bone effect or an age-dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to create rat sublines with constitutively high (high-5HT) and low (...

ba0005p94 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Automated ELISA for direct measurement of free 25OH vitamin D

Swinkels Leon , Huijs Tonnie , Geurts Marloes , Lindhout Ernst , Heuruex Nicolas , Martens Mike

Recent studies suggest that the concentration and genotype of vitamin D binding protein are important factors that determine the bioavailability of 25OH Vit-D in blood. It has been suggested that measurement of free, non-protein bound 25OH Vit-D in serum, may provide more relevant diagnostic information than total 25OH Vit-D, for instance in chronic kidney disease, bladder cancer and pancreatic cancer, or in hemodialysis patients.To measure free 25OH Vit...

ba0005p95 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Relationship between risk of preterm birth and vitamin D deficiency

Kim Tae-Hee , Won Byun Dong , Lee Hae-Hyeong , Hee Lee Seung , Kim Yeon-Suk

Background and objectives: Vitamin D deficiency causes calcium-depleted bone, which further weakens the bones and increases the risk of fractures. Also, It is known as related to obstetrics problem like gestational diabetes, infections, preeclampsia and incidence of caesarean section as well as glucose metabolism, immune system, cardiovascular diseases and cancer.Recently, the relationship between preterm birth and vitamin D deficiency becomes the main i...

ba0005p96 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Clinical characterization and genetic analysis of TRPV4-related skeletal dysplasias in 4 Chinese families

Chi Yue , Pang Qianqian , Xu Lijun , Jiang Yan , Li Mei , Wang Ou , Xing Xiaoping , Meng Xunwu , Zhou Xueying , Xia Weibo

TRPV4-associated skeletal dysplasias include: FDAB, ADBO, SMDK, SEDM, MD and Parastremmatic dysplasia. In this study, we recruited 3 families with congenital scoliosis and 1 family with localized digital osteopetrosis. We collected their clinical data and use the next-generation sequencing system, Sanger sequencing and RT-PCR to obtain the genetic diagnosis. Proband 1, 2, 3 all presented with early-onset kyphoscoliosis and short stature. X-ray showed platyspondyly, hemivertebr...

ba0005p97 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2016

Vitamin D therapy: the effects of race, skin colour and genotype

Sujatha Jaya , Kothandapani Gopal , Evans Lucy , Fatma Gossiel , Walsh Jennifer , Eastell Richard , Bishop Nick

Background: It is well established that Asians have lower levels of vitamin D (25OHD) when compared to Caucasians. Vitamin D binding protein (DBP) levels are also lower in some races than in Caucasians.Objectives: i) To find out whether DBP is lower in Asians; ii) To find out whether free 25OHD is lower in Asians; iii) To find out whether PTH is increased in Asians and interpret this in relation to 25OHD levels and iv) To find out whether the increment i...