Bone Abstracts

It is well established that estrogen, mainly via estrogen receptor alpha (ERα), has positive effects on bone, but estrogen is not considered as a treatment option against osteoporosis due to negative side-effects in other tissues. ERα is widely subjected to posttranslational modifications (PTMs), which can affect cellular responses to estrogen in a tissue specific manner by influencing the function of ERα and its interactions with other proteins. The in vivo...

Chronic stress and depression are associated with alterations in the hypothalamic-pituitary-adrenal signalling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Utilising a transgenic (tg) mouse model in which glucocorticoid signalling is selectively disrupted in mature osteoblasts and osteocytes (HSD2OB-tg mice), the current study examines the impact ...

Glucocorticoids (GCs) are widely used to treat acute and chronic inflammatory diseases such as acute lung injury (ALI) and rheumatoid arthritis (RA) and lead to multiple side effects including GC induced osteoporosis (GIO). Molecularly GCs act by binding to the GC receptor (GR), a ligand induced transcription factor. We discovered that pharmacologically GC exposure reprograms binding of GR monomers towards GR dimers (Genome Research 2015 25:836). Furthermore we challenged the ...