Purpose: PK-VF study, being conducted in 20072008 and 20122013, was aimed to investigate the prevalence and 5-year incidence of vertebral fractures (VFs) in postmenopausal women aged 50 years or older in Beijing, China.
Methods: In the 20072008 survey, we randomly selected a community-based population of 1825 postmenopausal women, of whom 952 women also participated in the 20122013 survey. Adopting the same sampling strategies as 20072008 survey, in the 20122013 survey, we additionally selected 1101 postmenopausal women, and a total of 2053 subjects were finally included. VFs were confirmed by the lateral radiographs of the thoracolumbar spine (T4-L5), being evaluated by two experienced radiologists. To investigate the secular trend of VFs, we standardized the prevalence of VFs in the 20122013 survey to the age composition of 20072008 population. Pearson χ2 test was conducted to compare the incidence of VFs between subjects with and without VFs in 20072008.
Results: The actual prevalence of VFs was 24.8% (95% CI, 22.826.8%) in 20072008, and 24.1% (95% CI, 22.326.0%) in 20122013. The age-standardized prevalence of VFs in 20122013 was 23.3% (95% CI, 21.525.1%) and was insignificantly decreased 0.94-fold (95% CI, 0.841.05), comparing to 20072008. The 5-year incidence of VFs during 20072012 period was 5.3% (95% CI, 3.86.7%). Comparing to subjects without VFs in 20072008, subjects with VFs had a 2.605-fold (95% CI, 1.4604.650) higher risk getting a new VF in the following 5 years.
Conclusions: The rates of VFs kept constant in postmenopausal women in Beijing, China, during 20072012. History of previous VF was a potential risk factor of incident VF.
14 May 2016 - 17 May 2016